Engineered T-Cells take aim at Hard-to-Treat cancers

NCT ID NCT02989064

First seen Feb 04, 2026 · Last updated May 12, 2026 · Updated 17 times

Summary

This early-stage trial tested a new treatment for people with bladder, skin, or head and neck cancers that have a specific marker called MAGE-A10. Doctors took patients' own immune cells, modified them in a lab to better attack cancer, and gave them back after a short course of chemotherapy. The main goal was to check safety and find the right dose, with 10 patients enrolled.

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Contacts and locations

Locations

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Hospital Universitario 12 Octubre Avda. de Córdoba

    Madrid, 28041, Spain

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G1X6, Canada

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Start Madrid-FJD, Fundación Jimѐnez Díaz

    Madrid, 28040, Spain

  • Tennessee Oncology - Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Vanderbilt - Ingram Cancer Center

    Nashville, Tennessee, 37203, United States

  • Washington University - School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.