Brain-Delivered gene therapy tested to halt devastating Early-Onset dementia
NCT ID NCT06064890
Summary
This early-phase study is testing a one-time gene therapy called AVB-101 for people with a specific genetic form of frontotemporal dementia (FTD-GRN). The therapy is designed to be delivered directly into the brain to restore a missing protein and potentially slow or stop disease progression. Researchers will primarily assess safety and early signs of effectiveness in a small group of participants over five years of follow-up.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Amsterdam UMC
RECRUITINGAmsterdam, Netherlands
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Cambridge University Hospitals NHS Foundation Trust
RECRUITINGCambridge, CB2 0QQ, United Kingdom
Contact Email: •••••@•••••
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Centrum Medyczne NeuroProtect Sp z o.o.
RECRUITINGWarsaw, Poland
Contact Email: •••••@•••••
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Euromedis Sp. z o.o.
RECRUITINGSzczecin, 70-111, Poland
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Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITINGMilan, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clinic Barcelona
RECRUITINGBarcelona, 08036, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari i Politecnic La Fe
RECRUITINGValencia, 46026, Spain
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Houston Methodist Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mazowiecki Szpital Brodnowski Sp. z o. o.
RECRUITINGWarsaw, Poland
Contact Email: •••••@•••••
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NEURO-CARE Sp. z o.o. Sp. Komandytowa
RECRUITINGKatowice, Poland
Contact Email: •••••@•••••
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Neurologia Slaska Centrum Medyczne
RECRUITINGKatowice, Poland
Contact Email: •••••@•••••
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Skåne University Hospital
RECRUITINGLund, Sweden
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Ohio State University (OSU) Wexner Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UZ Leuven
RECRUITINGLeuven, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University College London Hospitals
RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital of Wales
RECRUITINGCardiff, CF14 4XW, United Kingdom
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Uniwersyteckie Centrum Kliniczne, SUM w Katowicach
RECRUITINGKatowice, Poland
Contact Email: •••••@•••••
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Vanderbilt University Medical Centre
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.