One-Shot gene therapy could end monthly eye injections for millions

NCT ID NCT04704921

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

Summary

This study is testing a one-time gene therapy called RGX-314 for wet age-related macular degeneration (wet AMD), a leading cause of vision loss. It aims to help the eye make its own medicine to control leaky blood vessels, potentially reducing or eliminating the need for lifelong, frequent eye injections. The trial will compare the gene therapy's effectiveness and safety against the current standard injection treatment in about 630 participants.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Advanced Research, LLC /ID# 275451
RECRUITING

Deerfield Beach, Florida, 33064-1342, United States
Associated Retinal Consultants /ID# 256156
RECRUITING

Royal Oak, Michigan, 48073, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 270767
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Austin Clinical Research, LLC /ID# 256043
RECRUITING

Austin, Texas, 78750-2298, United States
Austin Research Center for Retina /ID# 256148
RECRUITING

Austin, Texas, 78705, United States
Austin Retina Associates - Austin /ID# 256053
RECRUITING

Austin, Texas, 78705, United States
Barnet Dulaney Perkins Eye Center - Sun City /ID# 256055
RECRUITING

Sun City, Arizona, 85351, United States
Bascom Palmer Eye Institute - University of Miami /ID# 256072
COMPLETED

Miami, Florida, 33136, United States
Baylor Scott & White Surgicare /ID# 256122
RECRUITING

Fort Worth, Texas, 76104, United States
Black Hills Regional Eye Institute /ID# 256161
RECRUITING

Rapid City, South Dakota, 57701, United States
California Eye Specialists Medical Group Inc. /ID# 256079
RECRUITING

Pasadena, California, 91107, United States
California Retina Consultants - Santa Barbara /ID# 256017
COMPLETED

Santa Barbara, California, 93103, United States
Charles Retina Institute /ID# 256016
RECRUITING

Germantown, Tennessee, 38138, United States
Charleston Neuroscience Institute /ID# 256235
RECRUITING

Ladson, South Carolina, 29456, United States
Cincinnati Eye Institute- Edgewood /ID# 256132
RECRUITING

Edgewood, Kentucky, 41017-3415, United States
Cleveland Clinic Main Campus /ID# 256064
RECRUITING

Cleveland, Ohio, 44195, United States
Colorado Retina Associates /ID# 256121
RECRUITING

Lakewood, Colorado, 80228, United States
Cumberland Valley Retina Consultants - Hagerstown /ID# 256151
RECRUITING

Hagerstown, Maryland, 21740, United States
Duke Eye Center /ID# 256076
RECRUITING

Durham, North Carolina, 27705, United States
Erie Retina Research /ID# 256154
RECRUITING

Erie, Pennsylvania, 16507, United States
Eye Associates of New Mexico /ID# 256075
RECRUITING

Albuquerque, New Mexico, 87109, United States
Florida Retina Consultants /ID# 265661
RECRUITING

Lakeland, Florida, 33805, United States
Georgia Retina - Marietta /ID# 256142
RECRUITING

Marietta, Georgia, 30060, United States
John A. Moran Eye Center /ID# 256068
RECRUITING

Salt Lake City, Utah, 84132, United States
John-Kenyon American Eye Institute -New Albany /ID# 256065
RECRUITING

New Albany, Indiana, 47150-3620, United States
Johns Hopkins Hospital /ID# 256015
RECRUITING

Baltimore, Maryland, 21287, United States
Long Island Vitreoretinal Consultants /ID# 256074
COMPLETED

Great Neck, New York, 11021, United States
Marietta Eye Clinic /ID# 268163
RECRUITING

Marietta, Georgia, 30060, United States
Mayo Clinic - Minnesota /ID# 256051
RECRUITING

Rochester, Minnesota, 55905, United States
Mid Atlantic Retina /ID# 256013
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Northern California Retina Vitreous Associates Medical Group, Inc /ID# 256298
RECRUITING

Mountain View, California, 94040-4101, United States
Ochsner Medical Center - Jefferson Highway /ID# 270524
RECRUITING

New Orleans, Louisiana, 70121, United States
Ophthalmic Consultants of Boston /ID# 256014
RECRUITING

Boston, Massachusetts, 02114, United States
Orange County Retina Medical Group /ID# 256073
RECRUITING

Santa Ana, California, 92705, United States
Pacific Northwest Retina /ID# 256155
COMPLETED

Bellevue, Washington, 98004, United States
Retina Associates - Lenexa /ID# 256080
RECRUITING

Lenexa, Kansas, 66215, United States
Retina Associates of Cleveland-Middleburg Heights /ID# 256052
RECRUITING

Cleveland, Ohio, 44130, United States
Retina Associates of Michigan /ID# 266198
RECRUITING

Grand Blanc, Michigan, 48439, United States
Retina Associates of New Orleans /ID# 272440
RECRUITING

Metairie, Louisiana, 70006-2940, United States
Retina Associates of Utah /ID# 256044
RECRUITING

Salt Lake City, Utah, 84107, United States
Retina Center NW, PLLC /ID# 256157
RECRUITING

Silverdale, Washington, 98383, United States
Retina Center Of Texas (Rct) - Southlake /ID# 256056
RECRUITING

Southlake, Texas, 76092, United States
Retina Consultants - The Woodlands /ID# 256018
RECRUITING

The Woodlands, Texas, 77384, United States
Retina Consultants Of Texas /ID# 268611
RECRUITING

San Antonio, Texas, 78240, United States
Retina Consultants of Hawaii /ID# 256049
RECRUITING

‘Aiea, Hawaii, 96701, United States
Retina Consultants of Orange County /ID# 256152
RECRUITING

Fullerton, California, 92835, United States
Retina Consultants of San Diego /ID# 256021
RECRUITING

Poway, California, 92064-2530, United States
Retina Consultants of Southern Colorado /ID# 256069
RECRUITING

Colorado Springs, Colorado, 80909, United States

Contact Phone: •••-•••-••••
Retina Consultants of Texas - Beaumont /ID# 266279
RECRUITING

Beaumont, Texas, 77707, United States
Retina Group of New England - Waterford /ID# 256071
COMPLETED

Waterford, Connecticut, 06385-1215, United States
Retina Northwest, PC /ID# 256140
RECRUITING

Portland, Oregon, 97221, United States
Retina Partners Midwest, PC /ID# 256045
RECRUITING

Indianapolis, Indiana, 46290, United States
Retina Research Institute of Texas /ID# 256141
RECRUITING

Abilene, Texas, 79606-1224, United States
Retina Specialty Institute /ID# 256153
RECRUITING

Pensacola, Florida, 32503, United States

Contact Phone: •••-•••-••••
Retina Vitreous Assoc Med Grp /ID# 256299
RECRUITING

Beverly Hills, California, 90211, United States
Retina Vitreous Associates of Florida - St. Petersburg /ID# 256050
RECRUITING

St. Petersburg, Florida, 33711-1141, United States
Retina Vitreous Center, Research /ID# 256067
RECRUITING

Edmond, Oklahoma, 73013, United States
Retina Vitreous Consultants - Monroeville /ID# 271654
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact Phone: •••-•••-••••
Retina and Vitreous of Texas /ID# 263961
RECRUITING

Bellaire, Texas, 77401, United States
Retina-Vitreous Surgeons of Central New York - Liverpool /ID# 266274
RECRUITING

Liverpool, New York, 13088, United States
Retinal Consultants Medical Group /ID# 256047
RECRUITING

Sacramento, California, 95825, United States
Retinal Diagnostic Center /ID# 256137
RECRUITING

Campbell, California, 95008, United States
Retinal Research Institute /ID# 256019
RECRUITING

Phoenix, Arizona, 85053, United States

Contact Phone: •••-•••-••••
Salehi Retina Institute /ID# 263485
RECRUITING

Huntington Beach, California, 92647, United States
Sierra Eye Associates /ID# 256020
RECRUITING

Reno, Nevada, 89502, United States
Southeast Retina Center /ID# 256022
RECRUITING

Augusta, Georgia, 30909, United States
Southern Vitreoretinal Associates /ID# 256158
RECRUITING

Tallahassee, Florida, 32308, United States
Southwest Retina Research Center /ID# 256136
RECRUITING

Durango, Colorado, 81303, United States
Springfield Clinic /ID# 266225
RECRUITING

Springfield, Illinois, 62702-3749, United States
Stone Oak Surgery Center /ID# 266199
COMPLETED

San Antonio, Texas, 78240, United States
Texas Retina Associates - Dallas /ID# 256133
RECRUITING

Dallas, Texas, 75231, United States
The Retina Care Center /ID# 256144
RECRUITING

Baltimore, Maryland, 21209, United States
The Retina Group Of Washington - Chevy Chase /ID# 276039
RECRUITING

Chevy Chase, Maryland, 20815, United States
The Retina Institute /ID# 266587
RECRUITING

St Louis, Missouri, 46214, United States
The Retina Partners - Encino /ID# 256054
RECRUITING

Encino, California, 91436, United States
Thomas Eye Group PC /ID# 268159
RECRUITING

Sandy Springs, Georgia, 30328-4411, United States
UC Irvine/Gavin Herbert Eye Institute /ID# 256145
COMPLETED

Irvine, California, 92697, United States
UCLA Doheny Eye Center /ID# 256120
RECRUITING

Pasadena, California, 91105, United States
University Retina and Macula Associates /ID# 256077
RECRUITING

Oak Forest, Illinois, 60452, United States
University Retina and Macula Associates /ID# 256078
RECRUITING

Lemont, Illinois, 60439, United States
University of Arkansas for Medical Sciences /ID# 271290
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California, San Francisco /ID# 256130
RECRUITING

San Francisco, California, 94143, United States
University of Illinois at Chicago /ID# 256300
COMPLETED

Chicago, Illinois, 60607, United States
University of Wisconsin-Madison, Department of Ophthalmology and Visual Sciences /ID# 256159
COMPLETED

Madison, Wisconsin, 53705-3644, United States
Verum Research, LLC /ID# 266585
RECRUITING

Eugene, Oregon, 97401, United States
VitreoRetinal Surgery PLLC DBA Retina Consultants of Minnesota /ID# 256160
RECRUITING

Edina, Minnesota, 55435, United States
Vitreoretinal Associates, P.A. /ID# 256150
RECRUITING

Gainesville, Florida, 32607, United States
Wagner Macula & Retina Center - Norfolk /ID# 256134
RECRUITING

Norfolk, Virginia, 23502, United States
West Coast Retina /ID# 256448
RECRUITING

San Francisco, California, 94107, United States

Conditions

Explore the condition pages connected to this study.

AMD CHOROIDAL NEOVASCULARIZATION CNV NAMD NEOVASCULAR AGE-RELATED MACULAR DEGENERATION NEOVASCULAR AMD WAMD WET AGE-RELATED MACULAR DEGENERATION WET AMD