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New antibody drug trial offers hope for Tough-to-Treat cancers

NCT ID NCT04083599

Ongoing Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

Summary

This early-stage trial is testing a new antibody drug called GEN1042 to see if it's safe and can help control advanced solid tumors. Researchers are giving GEN1042 alone or combined with another cancer drug (pembrolizumab) to about 350 adults with cancers like lung, colorectal, melanoma, and pancreatic cancer that have spread or can't be removed by surgery. The study first finds the safest dose, then checks if the drug helps shrink tumors or slow cancer growth.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ARENSIA Research Clinic at the Oncology Institute

    Chisinau, Moldova

  • ARENSIA Research Clinic at the Research Institute of Clinical Medicine

    Tbilisi, Georgia

  • Adventist Health System/Sunbelt,Inc

    Seattle, Washington, 98109, United States

  • Alaska Oncology and Hematology LLC

    Anchorage, Alaska, 99508, United States

  • Azienda Ospedaliera S.Croce e Carle Cuneo

    Cuneo, Italy

  • Azienda Ospedaliera Spedali Civili di Brescia

    Brescia, Italy

  • Cancer & Blood Specialty Clinic

    Los Alamitos, California, 90720, United States

  • Centre Antoine Lacassagne

    Nice, France

  • Centre hospitalier Universitaire de Bordeaux

    Bordeaux, France

  • Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch

    Kaohsiung City, Taiwan

  • Chang Gung Memorial Hospital Linkou Branch

    Taoyuan District, Taiwan

  • China Medical University Hospital

    Taichung, Taiwan

  • ChristianaCare

    Newark, Delaware, 19713, United States

  • Chungbuk National University Hospital

    Cheongju-si, South Korea

  • Clinica Universidad de Navarra

    Madrid, Spain

  • Clinica Universidad de Navarra

    Pamplona, Spain

  • Complejo Hospitalario Universitario de Santiago (CHUS)

    Santiago de Compostela, Spain

  • Department of Dermatology, University of Mainz

    Mainz, Germany

  • Florida Cancer Affiliates

    Ocala, Florida, 34474, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Gachon University Gil Medical Center

    Namdong, South Korea

  • Gustave Roussy

    Villejuif, France

  • H. Vall d'Hebron

    Barcelona, Spain

  • HM CIOCC Hospital Universitario HM Sanchinarro

    Madrid, Spain

  • Herlev University Hospital

    Herlev, Denmark

  • Hope and Healing Cancer Services

    Hinsdale, Illinois, 60521, United States

  • Hospital Clinico San Carlos

    Madrid, Spain

  • Hospital Clinico Universitario de Valencia

    Valencia, Spain

  • Hospital Duran i Reynals - ICO L Hospitalet

    L'Hospitalet de Llobregat, Spain

  • Hospital General Universitario Gregorio Maran

    Madrid, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Spain

  • Hospital Universitario Insular de Gran Canaria

    Las Palmas de Gran Canaria, 35016, Spain

  • Hospital Universitario La Paz

    Madrid, Spain

  • Hospital Universitario Lucus Augusti

    Lugo, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, Spain

  • Hospital Virgen del Rocio

    Seville, Spain

  • Istituto Clinico Humanitas

    Rozzano, Italy

  • Istituto Nazionale dei Tumori

    Milan, Italy

  • Jeonbuk National University Hospital

    Jeonju, South Korea

  • Kaiser Permanente (KP) Oncology/Hematology

    Portland, Oregon, 97227, United States

  • Kaohsiung Medical University Memorial Hospital

    Kaohsiung City, Taiwan

  • Klinikum der Stadt Ludwigshafen am Rhein gGmbH

    Ludwigshafen, Germany

  • Korea University Guro Hospital

    Seoul, South Korea

  • Levine Cancer Center

    Charlotte, North Carolina, 28204, United States

  • Lumi Research

    Kingwood, Texas, 77339, United States

  • MD Anderson Cancer Center Madrid

    Madrid, Spain

  • Maryland Oncology Hematology PA

    Columbia, Maryland, 21044, United States

  • Medical Oncology Associates, PS

    Spokane, Washington, 99204, United States

  • Moores Cancer Center at the UC San Diego Health

    San Diego, California, 92037, United States

  • Mount Sinai Comprehensive Cancer Center

    Miami Beach, Florida, 33140, United States

  • National Cheng Kung University Hospital

    Tainan, Taiwan

  • Nationales Centrum fr Tumorerkrankungen NCT

    Heidelberg, Germany

  • Norton Cancer Institute

    Louisville, Kentucky, 40202, United States

  • Novant Health Cancer Institute - Forsyth (Medical Oncology)

    Winston-Salem, North Carolina, 27103, United States

  • Pusan National University Yangsan Hospital

    Yangsan, South Korea

  • Rabin Medical Center

    Petah Tikva, Israel

  • Rigshospitalet (Copenhagen University Hospital)

    Copenhagen, Denmark

  • Royal Marsden NHS Foundation Trust

    Sutton, United Kingdom

  • START Barcelona HM Nou Delfos

    Barcelona, Spain

  • START Madrid - Hospital Universitario Fundacion Jimenez Diaz

    Madrid, Spain

  • Samsung Medical Center

    Seoul, South Korea

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Severance Hospital, Yonsei University Health System

    Seoul, South Korea

  • Taipei Medical University Hospital

    Taipei, Taiwan

  • Taipei Veterans General Hospital, VGHTPE

    Taipei, Taiwan

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, Israel

  • Universitaetsklinikum Wuerzburg

    Würzburg, Germany

  • University Hospital of Southern Denmark, Vejle Hospital

    Vejle, Denmark

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Universitätsmedizin Mannheim Dermatologie

    Mannheim, Germany

  • Utah Cancer Specialists

    Salt Lake City, Utah, 84124, United States

  • Virgina Cancer Specialists

    Fairfax, Virginia, 22031, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Yale University Cancer Center

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

COLORECTAL CANCER (CRC) HEAD AND NECK SQUAMOUS CELL CARCINOMA HNSCC MALIGNANT SOLID TUMOR MELANOMA NON-SMALL CELL LUNG CANCER (NSCLC) PANCREATIC DUCTAL ADENOCARCINOMA (PDAC)