Tailored brain zaps show promise for tough depression

NCT ID NCT06003309

First seen Feb 18, 2026 · Last updated May 10, 2026 · Updated 11 times

Summary

This study tested whether customizing brain stimulation (called iTBS) to each person's brain activity could better treat depression that hasn't responded to medication. 75 adults with treatment-resistant depression received 20 sessions over 4 weeks, comparing fully personalized stimulation to standard or partially personalized approaches. The goal was to see if the personalized method improved brain connectivity and reduced depressive symptoms more effectively.

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Contacts and locations

Locations

  • Australian National University

    Canberra, 2601, Australia

  • University of California, San Diego

    La Jolla, California, 92093, United States

Conditions

Explore the condition pages connected to this study.