Tailored brain zaps show promise for tough depression

NCT ID NCT06003309

First seen Feb 18, 2026 · Last updated May 20, 2026 · Updated 13 times

Summary

This study tested whether customizing the frequency and location of a non-invasive brain stimulation technique called iTBS could better treat depression that hasn't responded to medication. 75 adults with moderate-to-severe depression received either fully personalized, partially personalized, or standard iTBS over 4 weeks. The goal was to see if the personalized approach improved brain connectivity and reduced depressive symptoms more than the standard method.

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Contacts and locations

Locations

  • Australian National University

    Canberra, 2601, Australia

  • University of California, San Diego

    La Jolla, California, 92093, United States

Conditions

Explore the condition pages connected to this study.