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Can a new anesthetic give surgeons a clearer view during sinus surgery?

NCT ID NCT07788157

Disease control Sponsor: Tongji Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial tests whether fospropofol disodium, a newer form of propofol, can improve the surgical field quality during endoscopic sinus surgery compared to standard propofol anesthesia. The study includes adults aged 18-65 with chronic rhinosinusitis who are scheduled for sinus surgery. Researchers will measure how clear the surgical field is, along with blood loss and recovery times, to see if fospropofol offers any advantage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fospropofol disodium, a water-soluble prodrug of propofol, used for anesthesia induction and maintenance, with or without sevoflurane.
What this could lead to
If fospropofol provides a clearer surgical field than propofol, it could become a preferred anesthetic for sinus surgery, potentially reducing complications and improving outcomes.
What could go wrong
This is a single-center trial with 144 participants, so results may not apply broadly. Fospropofol is a prodrug, and its effects on surgical field quality compared to propofol are not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 144 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age 18-65 years * ASA physical status I-II * BMI 18-35 kg/m² * diagnosed with chronic rhinosinusitis (with or without nasal polyps) and scheduled for elective endoscopic sinus surgery * provided written informed consent Exclusion Criteria: * uncontrolled hypertension or asthma * use of medications that may affect coagulation function (e.g., NSAIDs) within 1 week prior to surgery * pre-existing coagulation abnormalities * history of bleeding disorders * history of drug allergy (to propofol, fospropofol disodium, or sevoflurane) * other comorbidities, such as uncorrected congenital heart disease, neuromuscular disorders, or hepatic/renal dysfunction * recent participation in other clinical studies

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endoscopic sinus surgery Fospropofol disodium Total intravenous anesthesia

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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