Folic Acid's secret mechanism against spina bifida under the microscope
NCT ID NCT05500690
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 69 women who had a pregnancy affected by spina bifida to understand how folic acid might prevent the condition. Researchers measured changes in DNA methylation and folate levels after a short course of folic acid supplements. The goal is to uncover the biological mechanisms behind folic acid's protective effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Folic acid supplement (5 mg tablet)
What this could lead to
If successful, this could reveal how folic acid prevents spina bifida, potentially improving prevention strategies.
What could go wrong
This is a small, completed observational study, not a treatment trial. Results may not lead to immediate clinical changes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institute of Neurosciences and Hospital
Dhaka, 1207, Bangladesh