Folic Acid's secret mechanism against spina bifida under the microscope
NCT ID NCT05500690
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 69 women who had a pregnancy affected by spina bifida to understand how folic acid might prevent the condition. Researchers measured changes in DNA methylation and folate levels after a short course of folic acid supplements. The goal is to uncover the biological mechanisms behind folic acid's protective effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Folic acid supplement (5 mg tablet)
- What this could lead to
- If successful, this could reveal how folic acid prevents spina bifida, potentially improving prevention strategies.
- What could go wrong
- This is a small, completed observational study, not a treatment trial. Results may not lead to immediate clinical changes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institute of Neurosciences and Hospital
Dhaka, 1207, Bangladesh
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