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Poop pills and immunotherapy: a new hope for lung cancer?

NCT ID NCT05669846

Recruiting now Disease control Sponsor: Diwakar Davar Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a fecal transplant from a healthy donor, combined with the immunotherapy drug pembrolizumab, can help people with a certain type of advanced lung cancer (PD-L1 positive non-small cell lung cancer) that has not responded to previous treatments. The transplant is given via colonoscopy or capsules to restore healthy gut bacteria, which may boost the immune system's ability to fight cancer. The trial will enroll 26 participants and measure tumor shrinkage and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Healthy donor fecal microbiota transplant (FMT) and pembrolizumab
What this could lead to
If it works, this could offer a new treatment option for people with advanced lung cancer that has stopped responding to standard therapies.
What could go wrong
This is a small, early-phase study with only 26 participants, so results may not apply to everyone. The combination therapy may cause side effects like immune-related reactions or infections from the transplant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

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