New oral drug trial aims to tame MS in kids

NCT ID NCT07161258

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 12, 2026 · Updated 5 times

Summary

This study tests an oral drug called fenebrutinib in 12 children and adolescents aged 10 to 17 with relapsing multiple sclerosis. The goal is to see how the drug moves through the body, how safe it is, and whether it reduces new brain lesions seen on MRI. Participants can choose to continue the drug in an optional extension period after the initial dose exploration.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fenebrutinib (an oral drug that targets the immune system)
What this could lead to: If it works, this could provide a new treatment option for children and teens with relapsing multiple sclerosis, potentially reducing relapses and brain lesions.
What could go wrong: This is a small, early-phase study with only 12 participants, so results may not apply to everyone. The drug may cause side effects or not work as well as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSING MULTIPLE SCLEROSIS

Contacts and locations

Locations

Centro Clnico Acadmico - Braga, Associao (2CA-Braga)
RECRUITING

Braga, 4710-243, Portugal
Centro de Pesquisas Clinicas - CPCLIN
RECRUITING

São Paulo, São Paulo, 01228-200, Brazil
Clinstile S.A de C.V.
RECRUITING

Mexico City, Mexico CITY (federal District), 06700, Mexico
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario de La Princesa
RECRUITING

Madrid, 28006, Spain
INECO Neurociencias Orono
RECRUITING

Rosario, Santa Fe Province, S2000DTB, Argentina
Instituto de Neurologia de Curitiba - Hospital Ecoville
RECRUITING

Curitiba, Paraná, 81210-310, Brazil
Instytut "Pomnik - Centrum Zdrowia Dziecka"
RECRUITING

Warsaw, 04-730, Poland
L2IP ?Instituto de Pesquisas Clínicas Ltda.
RECRUITING

Brasília, Federal District, 70200-730, Brazil
Neurociencias Estudios Clinicos S.C.
RECRUITING

Culiacán, Sinaloa, 80020, Mexico
Nucleo de Pesquisa Clinica do Rio Grande do Sul NPCR
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Sanatorio del Sur S.A.
RECRUITING

San Miguel de Tucumán, T4000IDK, Argentina
UH of State NPC Danulo Halytsky NMU in Lviv CID, Clinic of Neurology and Neurosurgery
RECRUITING

Lviv, 79010, Ukraine
Unidade Local de Saude de Coimbra E P E
RECRUITING

Coimbra, 3000-602, Portugal
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, 60-355, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80 952, Poland

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