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New hope for myelofibrosis: fedratinib trial targets spleen shrinkage

NCT ID NCT04446650

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 31 times

Summary

This study tests the drug fedratinib in about 31 Japanese adults with a bone marrow cancer called myelofibrosis. The goal is to see if it safely shrinks an enlarged spleen and controls the disease. Participants take the drug daily, and doctors monitor side effects and response over several months.

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Contacts and locations

Locations

  • Local Institution - 001

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Local Institution - 002

    Aomori, 030-8553, Japan

  • Local Institution - 003

    Shinjyuku-ku, 160-0023, Japan

  • Local Institution - 004

    Bunkyō City, 113-8677, Japan

  • Local Institution - 005

    Isehara City, Kanagawa, 259-1193, Japan

  • Local Institution - 006

    Chūō, Yamanashi, 409-3898, Japan

  • Local Institution - 007

    Shinagawa-ku, Tokyo, 141-8625, Japan

  • Local Institution - 008

    Shinjuku, 162-8666, Japan

  • Local Institution - 009

    Nagasaki, 8528511, Japan

  • Local Institution - 010

    Kamogawa, 296-8602, Japan

  • Local Institution - 011

    Ōsaka-sayama, 589-8511, Japan

  • Local Institution - 012

    Miyazaki, 889-1692, Japan

  • Local Institution - 013

    Maebashi, 371-8511, Japan

  • Local Institution - 014

    Sapporo, 003-0006, Japan

  • Local Institution - 015

    Fukuoka, 812-8582, Japan

  • Local Institution - 016

    Osaka, 545-8586, Japan

  • Local Institution - 017

    Kitakyushu, 806-8501, Japan

  • Local Institution - 018

    Hitachi, Ibaraki, 317-0077, Japan

  • Local Institution - 019

    Takamatsu, 760-0017, Japan

  • Local Institution - 020

    Kumamoto, 8628655, Japan

  • Local Institution - 021

    Suwa, Nagano, 392-8510, Japan

Conditions

Explore the condition pages connected to this study.

PRIMARY MYELOFIBROSIS