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Poop pills could supercharge lung cancer therapy

NCT ID NCT07247786

Not yet recruiting Disease control Sponsor: Fundación GECP Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether fecal transplants from immunotherapy responders can improve outcomes in stage II-III non-small cell lung cancer. 68 patients will receive either standard treatment (Durvalumab + chemotherapy) or the same plus fecal transplant capsules. The main goal is to see if the transplant increases the rate of complete tumor disappearance after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Fecal microbiota transplant (FMT) capsules
What this could lead to
If it works, this could point toward a way to boost the effectiveness of standard lung cancer therapy by using healthy gut bacteria from patients who responded well to immunotherapy.
What could go wrong
This is a small, early-phase trial (68 patients) testing safety and feasibility first. The approach is experimental, and it is unknown if the transplant will meaningfully improve outcomes or cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma respiratory tract neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER RESPIRATORY TRACT NEOPLASM

Contacts and locations

Locations

  • Complexo Hospitalario Universitario De Santiago

    Santiago de Compostela, La Coruña, 15706, Spain

  • Complexo Hospitalario Universitario De Vigo

    Vigo, Vigo, 36204, Spain

  • Hospital Clinico San Carlos

    Madrid, Madrid, 28040, Spain

  • Hospital Clínico de Valencia

    Valencia, Valencia, 46010, Spain

  • Hospital General Universitario De Elche

    Elche, Alicante, 03203, Spain

  • Hospital General Universitario Morales Meseguer

    Murcia, Murcia, 30008, Spain

  • Hospital General Universitario de Alicante

    Alicante, Alicante, 03010, Spain

  • Hospital Universitari Quiron Dexeus

    Barcelona, Barcelona, 08028, Spain

  • Hospital Universitari Vall d' Hebron

    Barcelona, Barcelona, 08035, Spain

  • Hospital Universitario 12 De Octubre

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario Clínico San Cecilio

    Granada, Granada, 18007, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, Madrid, 28040, Spain

  • Hospital Universitario La Fe

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario Lucus Augusti

    Lugo, Lugo, 27003, Spain

  • Hospital Universitario Nuestra Señora de Candelaria

    Santa Cruz de Tenerife, Santa Cruz de Tenerife, 38010, Spain

  • Hospital Universitario Puerta de Hierro

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Regional de Málaga

    Málaga, Málaga, 29010, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Barcelona, 08041, Spain

  • ICO Badalona, Hospital Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • ICO Hospitalet

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

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