Can genetic screening help prevent cancer in underserved communities?

NCT ID NCT03426878

Completed Knowledge-focused Sponsor: Kaiser Permanente Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at whether offering exome sequencing (a detailed genetic test) along with tailored genetic counseling helps people at high risk for hereditary cancer syndromes understand their risk and take action. Nearly 1,000 adults from diverse backgrounds in Colorado and Oregon participated. The goal was to see how well this approach works in real-world primary care settings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exome sequencing and genetic counseling
What this could lead to: If successful, this could help tailor cancer risk assessment and genetic counseling for diverse populations, potentially leading to earlier detection and prevention.
What could go wrong: This is a completed observational study with a small sample size (967 participants) and focuses on feasibility and utility, not treatment outcomes. Results may not apply to all populations.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis hereditary breast ovarian cancer syndrome hereditary neoplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY CANCER SYNDROME

Contacts and locations

Locations

Denver Health

Denver, Colorado, 80204, United States
Kaiser Permanente Center for Health Research

Portland, Oregon, 97227, United States

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