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Can High-Intensity exercise turn back the immune clock and keep head and neck cancer away?

NCT ID NCT06851988

Prevention Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 24, 2026 · Last updated Sep 25, 2026 · Updated 1 time

Summary

Researchers are testing whether a high-intensity interval training (HIIT) program can slow immune aging and reduce the chance of cancer returning in people treated for head and neck cancer. The trial enrolls about 290 adults who have completed chemoradiotherapy. Participants do HIIT two to three times a week for 24 to 36 sessions and record their physical activity at home. The study measures changes in biological age, fitness, and quality of life to see if exercise offers a safe and effective way to support recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-intensity interval training (HIIT) exercise program
What this could lead to
If HIIT slows immune aging, it could become a low-cost add-on to standard care that helps head and neck cancer patients stay in remission longer.
What could go wrong
This is an early study with no control group, so any benefit could be due to other factors. HIIT is demanding and may not suit everyone after intensive cancer treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 290 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥20 2. Pathology:Squamous cell carcinoma 3. Need CCRT treatment 4. ECOG PS\<2 5. Agree with blood drawing, excise training, questionnaire Exclusion Criteria: 1. ECOG PS≥2 2. Unable to tolerate basic exercise, or CCRT treatment 3. Mental illness or any medical illness or concurrent illness that may be aggravated by exercise training or unmanageable 4. Any medical condition that unsuitable for exercise 5. Disagree to trial procedures: exercise, blood draws, questionnaire

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms head and neck squamous cell carcinoma Motor Activity tonsil cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Head and neck cancers - tonsils High-intensity interval training

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • TuCheng Hospital

    RECRUITING

    New Taipei City, 23652, Taiwan

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