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Could exercise reshape gut bacteria in fatty liver disease?

NCT ID NCT07697313

Not yet recruiting Disease control Sponsor: Horus University Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This trial investigates whether high-intensity interval training or moderate continuous exercise, combined with a Mediterranean diet, can improve gut bacteria and metabolic health in people with non-alcoholic fatty liver disease. Participants are adults aged 40-60 with obesity and fatty liver who have not exercised regularly. The study measures changes in gut short-chain fatty acids, blood lipids, and quality of life over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
exercise training (high-intensity interval training or moderate intensity continuous training) plus Mediterranean diet
What this could lead to
If successful, this could show that a specific exercise program improves gut bacteria and metabolic health in people with fatty liver, offering a drug-free way to manage the condition.
What could go wrong
This is a small, early-stage trial with 60 participants, so results may not apply to everyone. The effects on gut microbiota are measured indirectly and may not translate to clear health benefits.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-ALCOHOLIC FATTY LIVER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • out-patient clinic, faculty of physical therapy, Horus university

    Cairo, Egypt

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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