New heart valve fix without open surgery shows promise

NCT ID NCT04221490

First seen Jan 09, 2026 · Last updated May 04, 2026 · Updated 16 times

Summary

This study is testing a new device called the EVOQUE system to replace a leaky tricuspid valve without open-heart surgery. The goal is to see if it is safe and works well for people with moderate to severe valve leakage who still have symptoms despite medication. About 228 participants will be followed to check for complications and how much the valve leakage improves.

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Contacts and locations

Locations

  • Baylor Heart Hopsital Plano

    Plano, Texas, 75093, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • CHU Bordeaux, Hôpital Cardiologique Haut Lévêque

    Pessac, 33600, France

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Clinique Pasteur

    Toulouse, 31076, France

  • Columbia University Irving Medical Center / NYPH

    New York, New York, 10032, United States

  • Emory University

    Atlanta, Georgia, 30308, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • InselSpital University Hospital Bern

    Bern, 3010, Switzerland

  • Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (IUCPQ-ULaval)

    Québec, G1V 4G5, Canada

  • Massachusetts General Hospital Boston

    Boston, Massachusetts, 02114, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Northwestern University

    Evanston, Illinois, 60208, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Piedmont Heart Institute

    Atlanta, Georgia, 30309, United States

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1W8, Canada

  • St. Paul's Hospital Vancouver

    Vancouver, British Columbia, V6Z1Y6, Canada

  • Stanford University

    Stanford, California, 94305, United States

  • University of Virginia Health System

    Charlottesville, Virginia, 22908, United States

Conditions

Explore the condition pages connected to this study.