New heart valve shows promise in aortic stenosis patients

NCT ID NCT03417011

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 23 times

Summary

This study tested a new heart valve called Evolut PRO in 638 people with a narrowed aortic valve (aortic stenosis). The valve was implanted to replace the diseased valve and help blood flow. The main goal was to see how many patients were alive 30 days after the procedure, and the results met the safety target.

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Contacts and locations

Locations

  • AOU Presidio Gaspare Rodolico Policlinico

    Catania, Italy

  • Asklepios Klinik St. Georg

    Hamburg, Germany

  • Azienda Ospedaliera Ospedale Niguarda Cà Granda

    Milan, Italy

  • Azienda Ospedaliera Spedali Civili di Brescia

    Brescia, Italy

  • Azienda Ospedaliero Universitaria Pisana - Stabilimento di Cisanello

    Pisa, Italy

  • CHU Bordeaux

    Bordeaux, France

  • CHU de Liège - Hôpital du Sart Tilman

    Liège, Belgium

  • Catharina Ziekenhuis Eindhoven

    Eindhoven, Netherlands

  • Clinique Pasteur

    Toulouse, France

  • Complejo Hospitalario Universitario de Santiago de Compostela

    Santiago de Compostela, Spain

  • Deutsches Herzzentrum Berlin

    Berlin, Germany

  • Deutsches Herzzentrum München Klinik an der TU München

    Munich, Germany

  • Erasmus Medisch Centrum

    Rotterdam, Netherlands

  • Hadassah Medical Organisation

    Jerusalem, Israel

  • Herz- und Diabeteszentrum NRW - Ruhr-Universität Bochum

    Bad Oeynhausen, Germany

  • Herzzentrum Dresden GmbH Universitätsklinik

    Dresden, Germany

  • Herzzentrum Leipzig GmbH

    Leipzig, Germany

  • Hospital Universitario Central de Asturias

    Oviedo, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, Spain

  • Hôpital Henri Mondor

    Créteil, France

  • IRCCS Policlinico San Donato

    Milan, Italy

  • Inselspital - Universitätsspital

    Bern, Switzerland

  • LKH - Universitätsklinikum

    Graz, Austria

  • Onze Lieve Vrouwe Gasthuis

    Amsterdam, Netherlands

  • Oslo Universitetssykehus-Ullevål

    Oslo, Norway

  • Rabin Medical Center - Beilinson Hospital

    Petah Tikva, Israel

  • Rigshospitalet

    Copenhagen, Denmark

  • Royal Victoria Hospital - Belfast Health and Social Care Trust

    Belfast, United Kingdom

  • SANA Herzchirurgie Stuttgart GmbH

    Stuttgart, Germany

  • Sana-Herzzentrum Cottbus GmbH

    Cottbus, Germany

  • St. George's Hospital

    London, United Kingdom

  • The Royal Wolverhampton Hospitals NHS - New Cross Hospital

    Wolverhampton, United Kingdom

  • Turun Yliopistollinen Keskussairaala

    Turku, Finland

  • Universitair Ziekenhuis Antwerpen

    Antwerp, Belgium

  • University Medical Centre

    Ljubljana, Slovenia

  • Universitätsklinikum Bonn

    Bonn, Germany

  • Universitätsklinikum Düsseldorf

    Düsseldorf, Germany

  • Universitätsklinikum Essen

    Essen, Germany

  • Universtitätsspital Zürich

    Zurich, Switzerland

Conditions

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