Newer scope technique may outperform standard procedure for Cancer-Related bile duct blockage

NCT ID NCT05122858

Completed Disease control Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial compares two ways to open a blocked bile duct in people with advanced cancer: the standard ERCP procedure versus a newer approach called EUS-guided drainage using a special stent. The goal is to see which method keeps the bile duct open longer with fewer complications. The study enrolls 15 adults with malignant bile duct blockages that cannot be surgically removed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EUS-guided biliary drainage with a lumen-apposing metal stent (LAMS) versus ERCP
What this could lead to: If EUS-guided drainage proves safer and more effective, it could become the preferred first-line treatment for malignant bile duct blockages, reducing complications and re-interventions.
What could go wrong: This is a small, early-phase trial with only 15 participants, so results may not apply broadly. Both procedures carry risks like infection, bleeding, or stent failure.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY DRAINAGE ECHOGRAPHY ULTRASOUND ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY

Contacts and locations

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Locations

Hôpital Privé des Peupliers

Paris, 75013, France

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