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New study follows 400 patients on upadacitinib for ulcerative colitis

NCT ID NCT05496348

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jan 07, 2026 · Last updated Jun 22, 2026 · Updated 32 times

Summary

This study follows 400 adults with moderate to severe ulcerative colitis who are starting upadacitinib (RINVOQ) as part of their regular care. Researchers will track how well the drug controls symptoms like diarrhea and rectal bleeding over two years. The goal is to see if early improvement predicts long-term success. No extra tests or visits are required beyond standard care.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Alb-Donau Klinikum Blaubeuren, ADK GmbH für Gesundheit und Soziales /ID# 249923

    ACTIVE_NOT_RECRUITING

    Blaubeuren Abbey, 89143, Germany

  • Benner & Dommermuth /ID# 249896

    ACTIVE_NOT_RECRUITING

    Koblenz, Rhineland-Palatinate, 56068, Germany

  • Berner IBD Study Group /ID# 262315

    ACTIVE_NOT_RECRUITING

    Bern, 3012, Switzerland

  • Bethanien-Krankenhaus /ID# 260865

    ACTIVE_NOT_RECRUITING

    Frankfurt am Main, Hesse, 60389, Germany

  • Dr. Schirin-Sokhan /ID# 259158

    ACTIVE_NOT_RECRUITING

    Würselen, 52146, Germany

  • Dr.med. Johannes Behrendt Facharzt für Innere Medizin und Gastroenterologie /ID# 260516

    COMPLETED

    Brandenburg an der Havel, Brandenburg, 14776, Germany

  • Dres. Bauer/Doerflinger /ID# 251568

    ACTIVE_NOT_RECRUITING

    Freiburg im Breisgau, 79102, Germany

  • Dres. Krause/Schiffer /ID# 251727

    ACTIVE_NOT_RECRUITING

    Frechen, 50226, Germany

  • Dres. Mallach/Spelter /ID# 270912

    COMPLETED

    Wuppertal, North Rhine-Westphalia, 42103, Germany

  • Dres. Rehbehn/Skusa /ID# 252618

    ACTIVE_NOT_RECRUITING

    Solingen, 42651, Germany

  • Dres. Schick/Wesenberg /ID# 249977

    ACTIVE_NOT_RECRUITING

    Berlin, 10437, Germany

  • EOC Ospedale Regionale Lugano /ID# 277165

    ACTIVE_NOT_RECRUITING

    Lugano, Canton Ticino, 6900, Switzerland

  • Elisabeth Klinikum GmbH /ID# 252264

    ACTIVE_NOT_RECRUITING

    Schmalkalden, 98574, Germany

  • Evangelisches Krankenhaus Kalk /ID# 249987

    ACTIVE_NOT_RECRUITING

    Cologne, North Rhine-Westphalia, 51103, Germany

  • Frach/Hohaus, Dresden, DE /ID# 254979

    ACTIVE_NOT_RECRUITING

    Dresden, 01067, Germany

  • Friedrich-Ebert-Krankenhaus GmbH /ID# 249973

    ACTIVE_NOT_RECRUITING

    Neumünster, Schleswig-Holstein, 24534, Germany

  • Gastro Campus Research GbR /ID# 249983

    COMPLETED

    Münster, 48159, Germany

  • Gastroenterologe am Ettlinger Tor /ID# 249982

    ACTIVE_NOT_RECRUITING

    Karlsruhe, 76133, Germany

  • Gastroenterologie Opernstrasse Private Practice - Dr. Falk and Krause and Kuhn /ID# 251822

    ACTIVE_NOT_RECRUITING

    Kassel, Hesse, 34117, Germany

  • Gastroenterologisch - Hepatologisches MVZ Kiel GmbH /ID# 252623

    ACTIVE_NOT_RECRUITING

    Kiel, Schleswig-Holstein, 24146, Germany

  • Gastroenterologische Gemeinschaftspraxis /ID# 263633

    COMPLETED

    Heilbronn, 74072, Germany

  • Gastroenterologische Gemeinschaftspraxis Herne /ID# 249990

    ACTIVE_NOT_RECRUITING

    Herne, North Rhine-Westphalia, 44623, Germany

  • Gastroenterologische Gemeinschaftspraxis Minden /ID# 249914

    ACTIVE_NOT_RECRUITING

    Minden, North Rhine-Westphalia, 32423, Germany

  • Gastropraxis Magdeburg /ID# 249988

    ACTIVE_NOT_RECRUITING

    Magdeburg, 39104, Germany

  • Gemeinschaftspraxis Dr. med. Maik Weisflog Dr. med. Katrin Ende /ID# 249918

    ACTIVE_NOT_RECRUITING

    Erfurt, Thuringia, 99084, Germany

  • Gemeinschaftspraxis Drs. Denger und Pfitzner /ID# 249974

    ACTIVE_NOT_RECRUITING

    Friedrichsthal, Saarland, 66299, Germany

  • Gemeinschaftspraxis im Medicum /ID# 249930

    ACTIVE_NOT_RECRUITING

    Altenholz, Schleswig-Holstein, 24161, Germany

  • Gesellschaft für klinische Studien /ID# 254081

    ACTIVE_NOT_RECRUITING

    Leipzig, Saxony, 04105, Germany

  • Inselspital, Universitaetsspital Bern /ID# 260968

    ACTIVE_NOT_RECRUITING

    Bern, 3010, Switzerland

  • Interdisziplinaeres Crohn Colitis Zentrum /ID# 252622

    ACTIVE_NOT_RECRUITING

    Frankfurt am Main, Hesse, 60318, Germany

  • Internist. Facharztp. Dr. Palmai /ID# 251821

    ACTIVE_NOT_RECRUITING

    Bitterfeld-Wolfen, 06749, Germany

  • Internisten in Geldern /ID# 252068

    ACTIVE_NOT_RECRUITING

    Guelders, 47608, Germany

  • Internistische Praxisgemeinschaft Hanau GbR /ID# 254079

    ACTIVE_NOT_RECRUITING

    Hanau, 63452, Germany

  • Kepler Universitaetsklinikum GmbH /ID# 251868

    ACTIVE_NOT_RECRUITING

    Linz, Upper Austria, 4020, Austria

  • Klinikum Augsburg /ID# 249979

    COMPLETED

    Augsburg, Bavaria, 86156, Germany

  • Klinikum Chemnitz - Flemmingstraße /ID# 259156

    ACTIVE_NOT_RECRUITING

    Chemnitz, Saxony, 09116, Germany

  • Klinikum Darmstadt /ID# 267685

    COMPLETED

    Darmstadt, Hesse, 64283, Germany

  • Klinikum Lueneburg /ID# 249948

    ACTIVE_NOT_RECRUITING

    Lüneburg, Lower Saxony, 21339, Germany

  • Klinikum Worms gGmbH /ID# 269804

    ACTIVE_NOT_RECRUITING

    Worms, Rhineland-Palatinate, 67550, Germany

  • Krankenhaus Waldfriede /ID# 249900

    ACTIVE_NOT_RECRUITING

    Berlin-Zehlendorf, 14163, Germany

  • Krankenhaus der Barmherzigen Brueder Salzburg /ID# 251869

    ACTIVE_NOT_RECRUITING

    Salzburg, 5010, Austria

  • Krankenhaus der Barmherzigen Brueder Wien /ID# 251867

    ACTIVE_NOT_RECRUITING

    Vienna, State of Vienna, 1020, Austria

  • MVZ Doceins West GmbH /ID# 249915

    ACTIVE_NOT_RECRUITING

    Koblenz, 56068, Germany

  • MVZ Dres. Al-Kadi & Partner /ID# 249929

    ACTIVE_NOT_RECRUITING

    Iserlohn, 58644, Germany

  • MVZ Gastro Friedrichshain /ID# 249924

    ACTIVE_NOT_RECRUITING

    Berlin, 10249, Germany

  • MVZ Gastroenterologie Leverkusen /ID# 260512

    ACTIVE_NOT_RECRUITING

    Leverkusen, 51375, Germany

  • MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 249981

    ACTIVE_NOT_RECRUITING

    Berlin, 10825, Germany

  • Medius Klinik Nürtingen /ID# 255420

    COMPLETED

    Nürtingen, 72622, Germany

  • Medizinische Hochschule Hannover /ID# 254980

    ACTIVE_NOT_RECRUITING

    Hanover, Lower Saxony, 30625, Germany

  • Medizinisches Versorgungszentrum Portal 10 /ID# 249947

    ACTIVE_NOT_RECRUITING

    Münster, 48155, Germany

  • Medizinisches Versorgunszentrum Dachau /ID# 249945

    ACTIVE_NOT_RECRUITING

    Dachau, Bavaria, 85221, Germany

  • Mueller/Mueller-Ziehm, Hanover /ID# 252617

    ACTIVE_NOT_RECRUITING

    Hanover, Lower Saxony, 30449, Germany

  • Pc Docs /Id# 249921

    ACTIVE_NOT_RECRUITING

    Pirmasens, 66953, Germany

  • Praxis Dr. Berndt /ID# 252067

    COMPLETED

    Berlin, 10409, Germany

  • Praxis Dr. Burlefinger /ID# 259159

    ACTIVE_NOT_RECRUITING

    Munich, 80336, Germany

  • Praxis Dr. Grümmer /ID# 249925

    COMPLETED

    Potsdam, Brandenburg, 14471, Germany

  • Praxis Dr. Schiffelholz /ID# 252621

    COMPLETED

    Augsburg, 86150, Germany

  • Praxis Dr. Schwarz /ID# 251819

    ACTIVE_NOT_RECRUITING

    Hettstedt, 06333, Germany

  • Praxis Dr. Soellenboehmer /ID# 249985

    ACTIVE_NOT_RECRUITING

    Berlin, 14052, Germany

  • Praxis Dr. Spitz /ID# 252616

    ACTIVE_NOT_RECRUITING

    Berlin, 14163, Germany

  • Praxis Dr. Weber /ID# 256099

    ACTIVE_NOT_RECRUITING

    Jena, 07743, Germany

  • Praxis Dres Brendel /ID# 254078

    COMPLETED

    Nuremberg, 90449, Germany

  • Praxis Dres. Hurst/Simonis /ID# 255421

    ACTIVE_NOT_RECRUITING

    Darmstadt, Hesse, 64293, Germany

  • Praxis Dres. Preiss/Engelke /ID# 249919

    ACTIVE_NOT_RECRUITING

    Herne, 44649, Germany

  • Praxis S. Grüngreiff /ID# 249927

    ACTIVE_NOT_RECRUITING

    Berlin, 12683, Germany

  • Praxis S. Tetzlaff /ID# 253770

    ACTIVE_NOT_RECRUITING

    Buedelsdorf, Schleswig-Holstein, 24782, Germany

  • Praxis fuer Gastroenterologie - Heidelberg /ID# 249917

    ACTIVE_NOT_RECRUITING

    Heidelberg, Baden-Wurttemberg, 69121, Germany

  • Praxis fuer Gastroenterologie - Lubeck /ID# 249907

    ACTIVE_NOT_RECRUITING

    Lübeck, Schleswig-Holstein, 23560, Germany

  • Praxis fuer Gastroenterologie - Schwerin /ID# 252615

    ACTIVE_NOT_RECRUITING

    Schwerin, Mecklenburg-Vorpommern, 19057, Germany

  • Praxisgemeinschaft Jerichow Schulze /ID# 262931

    ACTIVE_NOT_RECRUITING

    Jerichow, Saxony-Anhalt, 39319, Germany

  • Private Practice - Dr. Johannes Janschek /ID# 255092

    ACTIVE_NOT_RECRUITING

    Dresden, Saxony, 01309, Germany

  • Private Practice - Dr. Kempelmann /ID# 249935

    ACTIVE_NOT_RECRUITING

    Tostedt, Free and Hanseatic City of Hamburg, 21255, Germany

  • Private Practice - Dr. Matthias Eichler /ID# 249933

    ACTIVE_NOT_RECRUITING

    Hamburg, 22041, Germany

  • Private Practice - Dr. Mechthild Kemper and Dr. Markus Dreck /ID# 249916

    ACTIVE_NOT_RECRUITING

    Coesfeld, North Rhine-Westphalia, 48653, Germany

  • Prof-med-stud.de /ID# 255419

    COMPLETED

    Munich, 80935, Germany

  • Rems-Murr-Klinikum Winnenden /ID# 278791

    COMPLETED

    Winnenden, Baden-Wurttemberg, 71364, Germany

  • St. Marien- und St. Annastiftskrankenhaus /ID# 273172

    ACTIVE_NOT_RECRUITING

    Ludwigshafen am Rhein, Rhineland-Palatinate, 67067, Germany

  • Städtisches Kh. Heinsberg GmbH /ID# 252624

    ACTIVE_NOT_RECRUITING

    Heinsberg, 52525, Germany

  • TUM Klinikum rechts der Isar /ID# 262176

    ACTIVE_NOT_RECRUITING

    Munich, Bavaria, 81675, Germany

  • Tappe/Miks/Delker, Hamm, DE /ID# 251729

    ACTIVE_NOT_RECRUITING

    Hamm, 59065, Germany

  • Thormann and Bethge /ID# 249897

    ACTIVE_NOT_RECRUITING

    Kiel, Schleswig-Holstein, 24105, Germany

  • Universitaetsklinik Heidelberg /ID# 249922

    ACTIVE_NOT_RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitaetsklinikum Carl Gustav Carus Dresden /ID# 249989

    ACTIVE_NOT_RECRUITING

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Halle (Saale) /ID# 254083

    COMPLETED

    Halle, 06120, Germany

  • Universitaetsklinikum Jena /ID# 253768

    ACTIVE_NOT_RECRUITING

    Jena, Thuringia, 07747, Germany

  • Universitaetsklinikum Jena /ID# 254371

    COMPLETED

    Jena, Thuringia, 07747, Germany

  • Universitaetsklinikum Leipzig /ID# 262612

    ACTIVE_NOT_RECRUITING

    Leipzig, Saxony, 04103, Germany

  • Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 249984

    COMPLETED

    Lübeck, Schleswig-Holstein, 23538, Germany

  • University Hospital Zurich /ID# 260966

    ACTIVE_NOT_RECRUITING

    Zurich, Canton of Zurich, 8091, Switzerland

  • Verein für Wissenschaft und Forschung /ID# 249928

    ACTIVE_NOT_RECRUITING

    Oldenburg, Lower Saxony, 26123, Germany

  • Zentrum fur Gastroenterologie und Hepatologie /ID# 260967

    RECRUITING

    Zurich, Canton of Zurich, 8048, Switzerland

  • Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 249971

    ACTIVE_NOT_RECRUITING

    Saarbrücken, Saarland, 66111, Germany

  • Zweite Gemeinnuutzige Krankenhaus GmbH DRK Kliniken Berlin Kopenick /ID# 262849

    ACTIVE_NOT_RECRUITING

    Berlin, 12559, Germany

  • bauchraum Gastroenterologisches Zentrum Dres. F. Kuehl, C. Hartmann, T. Klag BAG /ID# 251567

    COMPLETED

    Stuttgart, 70435, Germany

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

upadacitinib (RINVOQ)

What this could lead to

If successful, this could confirm that upadacitinib is an effective long-term treatment for moderate to severe ulcerative colitis, helping more patients manage their disease.

What could go wrong

This is an observational study, not a controlled trial, so results may be less definitive. Upadacitinib is already approved, but long-term effectiveness can vary, and some patients may not respond or may experience side effects.

Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS ULCERATIVE COLITIS