New pill could shield kids with sickle cell from stroke
NCT ID NCT05953584
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests a new medicine called etavopivat in 27 children aged 12-16 with sickle cell disease who are at higher risk for stroke. Participants take one daily pill for a year, and doctors use ultrasound to measure blood flow in the brain. The goal is to see if etavopivat can safely lower stroke risk, especially in those who cannot take or still have risk on standard hydroxyurea therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- etavopivat
- What this could lead to
- If successful, this could provide a new oral treatment to reduce stroke risk in children with sickle cell disease who are not helped by current therapies.
- What could go wrong
- This is a small, early-phase study with only 27 participants. It may not show clear benefit, and side effects or lack of efficacy could limit its use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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All India Institute of Medical Sciences (AIIMS), Raipur
RECRUITINGRaipur, Chhattisgarh, 492099, India
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All India Institute of Medical Sciences-Delhi
RECRUITINGDelhi, 110029, India
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Aminu Kano Teaching Hospital (AKTH)
RECRUITINGTarauni, 700101, Nigeria
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Indira Gandhi Government Medical College & Hospital
NOT_YET_RECRUITINGNagpur, 440018, India
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Lagos University Teaching Hospital, Lagos
RECRUITINGLagos, 102215, Nigeria
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Nirmal Hospital Pvt. Ltd.
RECRUITINGGujarat, 395002, India
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Sultan Qaboos University Hospital
RECRUITINGMuscat, Sultanet of Oman/Muscat/Al Khoud, 123, Oman
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Suretech Hospital and Research Centre Ltd.
RECRUITINGMaharashtra, 440012, India
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University of Ibadan, University College Hospital
RECRUITINGIbadan, 200285, Nigeria
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