New drug combo shows promise against esophageal cancer in early trial

NCT ID NCT04929392

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 24 times

Summary

This early-phase trial is testing whether giving a mix of chemotherapy, radiation, an immunotherapy drug (pembrolizumab), and a targeted therapy (lenvatinib) before surgery can better kill esophageal cancer cells. The study includes about 3 adults with cancer that hasn't spread. The main goal is to see if the cancer disappears completely after treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE I GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE II GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE II GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IIA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IIA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IIB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE III GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 ESOPHAGEAL ADENOCARCINOMA ESOPHAGEAL SQUAMOUS CELL CARCINOMA PATHOLOGIC STAGE I GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE I GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IC GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE II GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE II GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIIA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIIB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8