New combo treatment tested for rapid relief of suicidal thoughts

This study is testing whether a combination treatment works better than medication alone for quickly reducing suicidal thoughts. Researchers are comparing a nasal spray medication (esketamine) plus a brief talk therapy to the nasal spray by itself. They are enrolling adults aged 18-70 with depression and suicidal thoughts who haven't improved with prior treatments. The goal is to see if the combined approach leads to a greater reduction in suicidal thinking one week after treatment.