New hope for head and neck cancer: drug combo shows promise after standard treatment fails
NCT ID NCT06856213
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding a chemotherapy drug (paclitaxel) to a targeted therapy (cetuximab) works better than cetuximab alone for people with advanced head and neck cancer that has worsened after initial treatment. About 65 adults with recurrent or metastatic squamous cell carcinoma of the head and neck will be randomly assigned to one of two treatment groups. The goal is to see how many patients' tumors shrink or disappear.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centro Oncológico de Galicia (La Coruña)
RECRUITINGA Coruña, La Coruña, 15009, Spain
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Complejo Hospitalario de Navarra (Pamplona)
RECRUITINGPamplona, Navarre, 31008, Spain
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Complejo Hospitalario de Salamanca (Salamanca)
RECRUITINGSalamanca, Salamanca, 37007, Spain
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Hospital Clínico San Carlos
RECRUITINGMadrid, Madrid, 28040, Spain
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Hospital Clínico Universitario de Santiago de Compostela
RECRUITINGSantiago de Compostela, A Coruña, 15706, Spain
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Hospital Infanta Leonor (Madrid)
RECRUITINGVallecas, Madrid, 28031, Spain
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Hospital Regional Universitario de Málaga
RECRUITINGMálaga, Málaga, 29010, Spain
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Hospital Universitario 12 de Octubre (Madrid)
WITHDRAWNMadrid, Madrid, 28041, Spain
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Hospital Universitario Lucus Augusti
RECRUITINGLugo, Lugo, 27003, Spain
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Hospital Universitario Marqués de Valdecilla (Santander)
RECRUITINGSantander, Cantabria, 39008, Spain
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Hospital Universitario Virgen de Valme (Sevilla)
RECRUITINGSeville, Sevilla, 41014, Spain
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Hospital Universitario Virgen de las Nieves
RECRUITINGGranada, Granada, 18014, Spain
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Hospital Universitario Virgen del Rocío (Sevilla)
RECRUITINGSeville, Sevilla, 41013, Spain
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Hospital Universitario de Canarias (La laguna)
RECRUITINGSan Cristóbal de La Laguna, Santa Cruz de Tenerife, 38320, Spain
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Hospital Universitario de Toledo
RECRUITINGToledo, Toledo, 45007, Spain
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Instituto Catalán de Oncología - Badalona
RECRUITINGBadalona, Barcelona, 08916, Spain
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Instituto Catalán de Oncología - Hospital Duran i Reynals
RECRUITINGBarcelona, Barcelona, 08908, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New drug cocktail aims to tackle recurrent head and neck cancer
- New drug combo targets Hard-to-Treat head and neck cancers
- Promising drug cocktail targets Hard-to-Treat head and neck cancer
- New drug combo targets Hard-to-Treat head and neck cancer
- Promising combo therapy for head and neck cancer hits early snag
- Gut health boost may tame immunotherapy side effects in head and neck cancer