New drug duo aims to tackle lymphoma without chemo

NCT ID NCT05783609

Recruiting now Disease control Sponsor: Reid Merryman, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a combination of two drugs, epcoritamab and rituximab, can effectively treat follicular lymphoma in people who have not had any prior treatment. The trial will enroll about 100 adults with CD20-positive follicular lymphoma. The goal is to see how many patients achieve a complete metabolic response (no signs of active cancer) after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epcoritamab and rituximab
What this could lead to: If successful, this combination could offer a more effective first-line treatment for follicular lymphoma, potentially leading to longer remission without chemotherapy.
What could go wrong: This is an early phase 2 trial with only 100 participants, so results may not apply to all patients. Side effects from the immune-based drugs could be significant, and the treatment may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma indolent B-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOLLICULAR LYMPHOMA LOW GRADE NON-HODGKIN'S LYMPHOMA, ADULT

Contacts and locations

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Icahn School of Medicine at Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
The Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States

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