New hope for advanced endometrial cancer: immunotherapy combo trial shows promise
NCT ID NCT04463771
First seen Jan 07, 2026 · Last updated Jun 23, 2026 · Updated 21 times
Summary
This phase 2 study tested a drug called retifanlimab, which helps the immune system attack cancer, either alone or combined with other targeted drugs. It enrolled 206 women with advanced or metastatic endometrial cancer that had worsened after platinum-based chemotherapy. The goal was to see if these treatments could shrink tumors or slow the disease.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Advent Health Medical Group-Orlando 2501
Orlando, Florida, 32804, United States
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Alaska Womens Cancer Care Akwcc
Anchorage, Alaska, 99508, United States
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Alexandra General Hospital of Athens
Athens, 11528, Greece
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Arizona Oncology Associates
Tucson, Arizona, 85711, United States
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Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola - Malpighi
Bologna, 40138, Italy
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Barbara Ann Karmanos Cancer Hospital
Detroit, Michigan, 48201, United States
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Billings Clinic Cancer Center
Billings, Montana, 59101, United States
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Broward Health Medical Center
Fort Lauderdale, Florida, 33316, United States
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Cario - Centre Armoricain de Radiotherapie Imagerie Medicale Et Oncologie
Plérin, 22190, France
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Caucasus Medical Centre Llc
Tbilisi, 00186, Georgia
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Centre Hospitalier Universitaire de Liege - Sart Tilman
Liège, 04000, Belgium
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Centre de Lutte Contre Le Cancer - Institut de Cancerologie de L'Ouest - Rene Gauducheau
Saint-Herblain, 44800, France
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Charite - Campus Virchow-Klinikum
Berlin, 13353, Germany
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Chu Besancon Hospital Jean Minjoz
Besançon, 25000, France
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Chu Ucl Namur de Saint Elisabeth
Namur, 05000, Belgium
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Comitato Etico Fondazione Irccs Istituto Nazionale Dei Tumori Milano
Milan, 20133, Italy
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Comprehensive Cancer Centers of Nevada
Henderson, Nevada, 89074, United States
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Euromedica General Clinic of Thessaloniki
Thessaloniki, 54645, Greece
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European Institute of Oncology
Milan, 20141, Italy
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Fondazione Policlinico Universitario Agostino Gemelli Irccs
Roma, 00168, Italy
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Georgia Cancer Center
Augusta, Georgia, 30912, United States
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Ghent University Hospital
Ghent, 09000, Belgium
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H. Lee Moffitt Cancer Center and Research Institute Hospital
Tampa, Florida, 33612-9497, United States
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High Technology Hospital Medcenter
Batumi, 06000, Georgia
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Honorhealth
Phoenix, Arizona, 85016, United States
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Hospital Cochin Cancerologie
Paris, 75006, France
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Hygeia Hospital
Marousi, 15123, Greece
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INNOVA
Tbilisi, 00186, Georgia
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Institut Bergonie
Bordeaux, 33076, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Institut Jules Bordet
Brussels, 01000, Belgium
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Iov - Istituto Oncologico Veneto Irccs
Padova, 35128, Italy
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Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele
Milan, 20132, Italy
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Istituto Nazionale Tumori Irccs Fondazione Pascale
Naples, 80131, Italy
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Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori
Meldola, 47014, Italy
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Jsc Evex Hospitals
Kutaisi, 04600, Georgia
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Klinikum Kassel Gmbh
Kassel, 34125, Germany
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Laura & Isaac Perlmutter Cancer Ctr
New York, New York, 10016, United States
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Miami Cancer Institute
Miami, Florida, 33176, United States
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Midwest Cancer Care
Kansas City, Missouri, 64132, United States
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Minnesota Oncology-Maplewood
Coon Rapids, Minnesota, 55433, United States
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Mount Sinai Medical Center Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
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Multiprofile Clinic Consilium Medulla Llc
Tbilisi, 00186, Georgia
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New Mexico Cancer Care Alliance
Albuquerque, New Mexico, 87131, United States
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O.L.V Ziekenhuis
Aalst, 09300, Belgium
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Olive View Med Ctr
Sylmar, California, 91342, United States
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Ospedale Santa Maria Ca Foncello
Treviso, 31100, Italy
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Presidio Ospedaliero Di Summa Antonio Perrino
Brindisi, 72100, Italy
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Tennessee Oncology
Nashville, Tennessee, 37203, United States
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Texas Oncology San Antonio
San Antonio, Texas, 78240, United States
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Texas Oncology the Woodlands
Shenandoah, Texas, 77380, United States
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Texas Oncology-Austin Center
Austin, Texas, 78731, United States
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Texas Oncology-Fort Worth South Henderson
Fort Worth, Texas, 76104-3902, United States
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Texas Oncology-Tyler
Sioux Falls, South Dakota, 57104, United States
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The Ohio State University Wexner Medical Center Division of Gynecologic Oncology
Hilliard, Ohio, 43026, United States
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Todua Clinic, Llc
Tbilisi, 00112, Georgia
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UCLA Medical Hematology & Oncology
Los Angeles, California, 90048, United States
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Universitaire Ziekenhuis Leuven - Gasthuisberg
Leuven, 03000, Belgium
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Universitarsfrauenklinik Ulm
Ulm, 89075, Germany
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University Clinic Carl Gustav Carus Technical University Dresden
Dresden, 01307, Germany
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University Hospital of West Attica - Attikon
Athens, 12462, Greece
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University of North Carolina At Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Washington University
St Louis, Missouri, 63110, United States
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Willamette Valley Cancer Institute
Eugene, Oregon, 97401-8122, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
retifanlimab (a drug that helps the immune system fight cancer), sometimes combined with epacadostat, pemigatinib, INCAGN02385, or INCAGN02390
What this could lead to
If successful, this could point toward new treatment options for advanced endometrial cancer that has stopped responding to standard chemotherapy.
What could go wrong
This is a phase 2 study, so results are still early. The drug combinations may not work better than existing treatments, and side effects from immunotherapy can be serious.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.