New CIDP drug empasiprubart enters final phase of testing

NCT ID NCT07091630

Recruiting now Disease control Sponsor: argenx Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether empasiprubart, given by IV infusion, can help adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder that causes weakness and disability. The study will enroll 160 participants. For the first 6 months, some get the drug and some get a placebo; after that, everyone receives empasiprubart for 2 years. The main goal is to see if the drug reduces disability scores.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: empasiprubart (a biologic drug given by IV infusion)
What this could lead to: If it works, this could provide a new treatment option for CIDP that reduces disability and improves daily function.
What could go wrong: This is a phase 3 trial, but it is still experimental. The drug may not prove better than placebo, and side effects are possible. Results may not apply to all CIDP patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic inflammatory demyelinating polyradiculoneuropathy polyneuropathy, inflammatory demyelinating, chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY CIDP

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AP-HP - Hôpital Henri Mondor
ACTIVE_NOT_RECRUITING

Créteil, Val-de-Marne, 94000, France
AP-HP - Hôpital de la Pitié Salpétrière
ACTIVE_NOT_RECRUITING

Paris, Paris, 75013, France
Aleksandre Aladashvili Clinic
RECRUITING

Tbilisi, 102, Georgia
Aqualane Clinical Research
RECRUITING

Naples, Florida, 34105, United States
Astra Kliinik
RECRUITING

Tallinn, 11315, Estonia
Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) - Ospedale di Cattinara
ACTIVE_NOT_RECRUITING

Trieste, Friuli-VeneziaGiulia, 34149, Italy
CHU de Bordeaux - Hôpital
NOT_YET_RECRUITING

Bourdeaux, France

Contact Email: •••••@•••••
CHU de Lille - Hôpital Roger Salengro
ACTIVE_NOT_RECRUITING

Lille, Nord, 59000, France
CHU de Nice-Hôpital Pasteur
RECRUITING

Nice, 6001, France
Centrum Medyczne Neurologia Slaska
RECRUITING

Katowice, 40-689, Poland
Colorado Springs Neurological Associates
RECRUITING

Colorado Springs, Colorado, 80907, United States
Curatio JSC
RECRUITING

Tbilisi, 114, Georgia
Eginitio Hospital
RECRUITING

Athens, Greece
Fakultni nemocnice Brno
RECRUITING

Brno, 625 00, Czechia
First Medical Clinic LLC
RECRUITING

Batumi, Georgia
Fondazione Istituto Neurologico Nazionale Casimiro Mondino IRCCS
RECRUITING

Pavia, 27100, Italy
Fondazione Serena Onlus - Centro Clinico NeMO Brescia
ACTIVE_NOT_RECRUITING

Gussago, Brescia, 25064, Italy
Fujian Medical University Union Hospital - Yushan Campus
ACTIVE_NOT_RECRUITING

Fuzhou, Fujian, 350108, China
Gables Neurology
RECRUITING

Miami, Florida, 33133, United States
Galen Clinic - Warszawa
ACTIVE_NOT_RECRUITING

Warsaw, Poland
Geo Hospitals
RECRUITING

Tbilisi, 144, Georgia
Guangdong Provincial Hospital of Chinese Medicine
RECRUITING

Guangzhou, 510120, China
High Technology Hospital MedCenter Ltd
RECRUITING

Batumi, 6000, Georgia
INECO Neurociencias Oroño
ACTIVE_NOT_RECRUITING

Rosario, Argentina
IRCCS Azienda Ospedaliera Metropolitana - Ospedale Policlinico San Martino
RECRUITING

Genova, 16132, Italy
IRCCS Istituto delle Scienze Neurologiche di Bologna
RECRUITING

Bologna, 40139, Italy
Institute of Science Tokyo Hospital
ACTIVE_NOT_RECRUITING

Bunkyō-Ku, Tokyo, 113-8519, Japan
Instituto Médico de la Fundación Estudios Clínicos
RECRUITING

Rosario, S2000DEJ, Argentina
Instituto Privado Kremer
RECRUITING

Córdoba, X5004AOA, Argentina
Institutul de Neurologie si Neurochirurgie
RECRUITING

Chisinau, 2028, Moldova
Jo Ann Medical Center
RECRUITING

Tbilisi, 159, Georgia
Kepler Universitätsklinikum Linz - Med Campus III
ACTIVE_NOT_RECRUITING

Linz, Upper Austria, 4021, Austria
Korea University Guro Hospital
RECRUITING

Seoul, 08308, South Korea
LTD New Hospitals
RECRUITING

Tbilisi, 114, Georgia
Medical Center Medika 2005 - Branch Sofia
RECRUITING

Sofia, 1164, Bulgaria
Medstar Health Research Institute
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv. Naum EAD
ACTIVE_NOT_RECRUITING

Sofia, Sofia, 1113, Bulgaria
Nanfang Hospital Southern Medical University
RECRUITING

Guangzhou, 510515, China
National Neuromuscular Research Institute
RECRUITING

Austin, Texas, 78756, United States
National Neuroscience Institute
ACTIVE_NOT_RECRUITING

Singapore, Singapore
Nemocnica s poliklinikou S. Kukuru a.s. - Pentahospitals
RECRUITING

Michalovce, 071 01, Slovakia
NeuroCarePlus
RECRUITING

Houston, Texas, 77094, United States
Ospedale San Raffaele S.r.l.
RECRUITING

Milan, 20132, Italy
PSEG Centro de Pesquisa Clinica
RECRUITING

São Paulo, 04038-002, Brazil
Paradigm Health System
RECRUITING

Slidell, Louisiana, 70458, United States
Peking University First Hospital - Changqiao Campus
RECRUITING

Beijing, 100034, China
Penn Medicine University City
RECRUITING

Philadelphia, Pennsylvania, 19104-5545, United States
Penta Hospitals SK, a.s. - Rimavská Sobota
RECRUITING

Rimavská Sobota, 979 01, Slovakia
Petre Sarajishvili Institute of Neurology
RECRUITING

Tbilisi, 0112, Georgia
Rigshospitalet
ACTIVE_NOT_RECRUITING

Copenhagen, 2100, Denmark
S.C. Neurocity S.R.L
RECRUITING

Bucharest, Romania
SC Clubul Sanatatii SRL
RECRUITING

Campulung Muscel, 115100, Romania
SP ZOZ Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, 30-688, Poland
Saga University Hospital
RECRUITING

Saga, 849-0937, Japan
Salford Royal Hospital
RECRUITING

Salford, M6 8HD, United Kingdom
Samir Macwan, M.D., Inc. (S corporation)
RECRUITING

Rancho Mirage, California, 92270, United States
Seirei Hamamatsu Hospital
RECRUITING

Hiroshima, 430-8558, Japan
Semmelweis Egyetem Genomikai Medicina és Ritka Betegségek Intézete
RECRUITING

Budapest, 1082, Hungary
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Southern TOHOKU Medical Clinic
RECRUITING

Kōriyama, 963-8052, Japan
Spitalul Judetean de Urgenta Deva
RECRUITING

Deva, 330084, Romania
The National Hospital for Neurology and Neurosurgery - PPDS
ACTIVE_NOT_RECRUITING

London, WC1N3BG, United Kingdom
Universitair Medisch Centrum Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
University General Hospital of Alexandroupolis
ACTIVE_NOT_RECRUITING

Alexandroupoli, Evros, 68100, Greece
University Multiprofile Hospital for Active Treatment
RECRUITING

Pleven, 5803, Bulgaria
University Multiprofile Hospital for Active Treatment Aleksandrovska EAD
RECRUITING

Sofia, 1431, Bulgaria
University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD
RECRUITING

Sofia, 1606, Bulgaria
University of Alabama at Birmingham - 1720 University Blvd
ACTIVE_NOT_RECRUITING

Birmingham, Alabama, 35233, United States
Universitätsklinikum AKH Wien
RECRUITING

Vienna, 1090, Austria
Univerzitna nemocnica MARTIN
RECRUITING

Martin, 036 59, Slovakia
Xi'an Gaoxin Hospital
RECRUITING

Xi'an, 710075, China

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