New Two-Drug combo targets Hard-to-Treat myeloma in early trial

NCT ID NCT06215118

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study is testing whether a combination of two drugs—elranatamab (given as a shot) and iberdomide (taken as a pill)—is safe and tolerable for people with multiple myeloma that has returned or stopped responding to prior treatments. The trial will enroll about 87 participants and has two parts: first to check safety, then to find the right dose. It is not a cure, but if successful, it could provide a new way to control this blood cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elranatamab (a drug that helps the immune system attack cancer cells) and iberdomide (a pill that targets cancer cells)
What this could lead to: If this combination proves safe and effective, it could offer a new treatment option for people with multiple myeloma that has returned or stopped responding to other therapies.
What could go wrong: This is a very early (Phase 1) study with only 87 participants, so it is primarily testing safety and dosing. The combination may not work well or could cause serious side effects. It is not a cure and will likely require ongoing treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CIUSSS de l'Est-de-l'Île-de-Montréal
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute - Chestnut Hill
RECRUITING

Newton, Massachusetts, 02459, United States
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Dr. Everett Chalmers Regional Hospital
RECRUITING

Fredericton, New Brunswick, E3B 5N5, Canada
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Epworth Freemasons
RECRUITING

East Melbourne, Victoria, 3002, Australia
Epworth Hospital
RECRUITING

Richmond, Victoria, 3121, Australia
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Indiana CTSI Clinical Research Center (ICRC)
RECRUITING

Indianapolis, Indiana, 46202, United States
Indiana University Health University Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC)
RECRUITING

Indianapolis, Indiana, 46202, United States
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia
MSK Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
MSK Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
MSK Commack
RECRUITING

Commack, New York, 11725, United States
MSK Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
MSK Nassau
RECRUITING

Uniondale, New York, 11553, United States
MSK Westchester
RECRUITING

Harrison, New York, 10604, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
RECRUITING

New York, New York, 10021, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
RECRUITING

Long Island City, New York, 11101, United States
Memorial Sloan Kettering Cancer Center - Main Campus
RECRUITING

New York, New York, 10065, United States
Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States
Oncology Hematology West P.C. dba Nebraska Cancer - Methodist
RECRUITING

Omaha, Nebraska, 68114, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
Slade Pharmacy
RECRUITING

Richmond, Victoria, 3121, Australia
Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
RECRUITING

Coral Gables, Florida, 33146, United States
Sylvester Comprehensive Cancer Center Kendall
RECRUITING

Miami, Florida, 33176, United States
Sylvester Comprehensive Cancer Center Plantation
RECRUITING

Plantation, Florida, 33324, United States
Sylvester Comprehensive Cancer Center- Doral
RECRUITING

Doral, Florida, 33166, United States
Townsville University Hospital
RECRUITING

Douglas, Queensland, 4814, Australia
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Massachusetts Chan Medical School
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Miami Hospital and Clinics
RECRUITING

Miami, Florida, 33136, United States
University of Miami Hospital and Clinics Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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