Promising new combo aims to control multiple myeloma without transplant

NCT ID NCT05623020

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests whether a new drug combination (elranatamab, daratumumab, and lenalidomide) works better than a standard combination for people newly diagnosed with multiple myeloma who are not eligible for a stem cell transplant. The trial involves about 1,116 participants and will measure how long the cancer stays under control and whether it can be reduced to undetectable levels. The goal is to improve disease control, not to cure the disease, as ongoing treatment is expected.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

"Theagenio" Cancer Hospital of Thessaloniki
RECRUITING

Thessaloniki, Kentrikí Makedonía, 540 07, Greece
A.O.U. Policlinico Paolo Giaccone
RECRUITING

Palermo, Sicily, 90127, Italy
AOU Policlinico Umberto I
RECRUITING

Roma, 00161, Italy
ASL PESCARA-Presidio Ospedaliero Pescara
RECRUITING

Pescara, 65124, Italy
AUSL di Piacenza
RECRUITING

Piacenza, Emilia-Romagna, 29121, Italy
AZ Delta vzw
RECRUITING

Roeselare, West-vlaanderen, 8800, Belgium
Albert Schweitzer Ziekenhuis, locatie Dordwijk
RECRUITING

Dordrecht, South Holland, 3318 AT, Netherlands
Alexandra General Hospital of Athens
RECRUITING

Athens, Attikí, 115 28, Greece
Auckland City Hospital
RECRUITING

Grafton, Auckland, 1023, New Zealand
Auxilio Mutuo Cancer Center
NOT_YET_RECRUITING

San Juan, 00917, Puerto Rico
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, Tuscany, 56126, Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
RECRUITING

Turin, Piedmont, 10126, Italy
Azienda Sanitaria Locale di Pescara
RECRUITING

Pescara, 65124, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
RECRUITING

Bergamo, 24127, Italy
CHUS - Hospital Clinico Universitario
RECRUITING

Santiago de Compostela, A Coruña [LA Coruña], 15706, Spain
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
RECRUITING

Nantes, 44093 Cedex 1, France
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet
RECRUITING

Nice, Alpes-maritimes, 06200, France
Centre Hospitalier Universitaire de Poitiers
RECRUITING

Poitiers, Vienne, 86021, France
Chang Gung Medical Foundation-Linkou Branch
RECRUITING

Taoyuan, 333, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 404332, Taiwan
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun-gun, Jeonranamdo, 58128, South Korea
Clinica Universidad de Navarra
RECRUITING

Madrid, Madrid, Comunidad de, 28027, Spain
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinique Saint Pierre
NOT_YET_RECRUITING

Ottignies, Brabant Wallon, 1340, Belgium
Cro-Irccs
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy
Cross Cancer Institute
NOT_YET_RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Dr. Everett Chalmers Regional Hospital
NOT_YET_RECRUITING

Fredericton, New Brunswick, E3B 5N5, Canada
Epworth Freemasons
RECRUITING

Melbourne, Victoria, 3002, Australia
Epworth Healthcare
RECRUITING

Richmond, Victoria, 3121, Australia
Evangelismos General Hospital of Athens
RECRUITING

Athens, Attikí, 106 76, Greece
Evangelismos General Hospital of Athens
RECRUITING

Athens, 10676, Greece
Fakultni nemocnice Olomouc
RECRUITING

Olomouc, 779 00, Czechia
Fakultní nemocnice Brno Bohunice
RECRUITING

Brno, Brno-město, 625 00, Czechia
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING

Monza, Lombardy, 20900, Italy
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, Fujian, 350001, China
Grand Hôpital de Charleroi
RECRUITING

Gilly, Hainaut, 6060, Belgium
Gunma University Hospital
RECRUITING

Maebashi, Gunma, 371-8511, Japan
H.R.U Málaga - Hospital General
RECRUITING

Málaga, 29010, Spain
Hadassah Medical Center
RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
RECRUITING

Helsinki, 00029, Finland
Hospital Clínic de Barcelona
RECRUITING

Barcelona, Catalunya [cataluña], 08036, Spain
Hospital La Princesa
RECRUITING

Madrid, 28006, Spain
Hospital San Pedro de Alcántara
RECRUITING

Cáceres, 10003, Spain
Hospital Universitari Mutua Terrassa
RECRUITING

Terrassa, Barcelona [barcelona], 08221, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Doctor Peset
RECRUITING

Valencia, València, 46017, Spain
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
NOT_YET_RECRUITING

Ribeirão Preto, São Paulo, 14051-140, Brazil
Hôpital Saint Antoine
NOT_YET_RECRUITING

Paris, 75012, France
IRCCS Casa Sollievo della Sofferenza
RECRUITING

San Giovanni Rotondo, FG, 71013, Italy
IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino Amadori- IRST S.r.l
RECRUITING

Meldola (Fc), Emilia-Romagna, 47014, Italy
Institut Català d'Oncologia (ICO) - Badalona
RECRUITING

Badalona, Barcelona [barcelona], 08916, Spain
Institut Català d'Oncologia (ICO) - Girona
RECRUITING

Girona, Girona [gerona], 17007, Spain
Institut Català d'Oncologia - L'Hospitalet
RECRUITING

L'Hospitalet Del Llobregat, Barcelona [barcelona], 08908, Spain
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE
RECRUITING

Toulouse, Haute-garonne, 31100, France
Institute of hematology&blood disease hospital
RECRUITING

Tianjin, Tianjin Municipality, 300020, China
Istituto Europeo di Oncologia IRCCS
RECRUITING

Milan, 20141, Italy
Iwate Medical University Hospital
RECRUITING

Yahaba-cho, Iwate, 028-3695, Japan
Japanese Red Cross Medical Center
RECRUITING

Shibuya-ku, Tokyo, 150-8935, Japan
Jupiter Medical Center/Anderson Family Cancer Institute
NOT_YET_RECRUITING

Jupiter, Florida, 33458, United States
Kantonsspital Winterthur
NOT_YET_RECRUITING

Winterthur, 8401, Switzerland
Klinikum Chemnitz
RECRUITING

Chemnitz, 09116, Germany
Kuopion Yliopistollinen Sairaala
RECRUITING

Kuopio, Northern Savonia, 70210, Finland
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
Landeskrankenhaus Feldkirch
NOT_YET_RECRUITING

Rankweil, Vorarlberg, 6830, Austria
Leicester Royal Infirmary
RECRUITING

Leicester, England, LE1 5WW, United Kingdom
MSK Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
MSK Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
MSK Commack
RECRUITING

Commack, New York, 11725, United States
MSK Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
MSK Nassau
RECRUITING

Uniondale, New York, 11553, United States
MSK Westchester
RECRUITING

Harrison, New York, 10604, United States
Medizinische Universität Graz
RECRUITING

Graz, Styria, 8036, Austria
Medizinische Universität Wien
NOT_YET_RECRUITING

Vienna, 1090, Austria
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
RECRUITING

New York, New York, 10021, United States
Memorial Sloan Kettering Cancer Center-Main Campus
RECRUITING

New York, New York, 10065, United States
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, Jiangsu, 210008, China
National Hospital Organization Okayama Medical Center
RECRUITING

Okayama, 701-1192, Japan
National Taiwan University Hospital
ACTIVE_NOT_RECRUITING

Taipei, 10002, Taiwan
North Shore Hospital
RECRUITING

Auckland, 0622, New Zealand
Nova Scotia Health Authority
RECRUITING

Halifax, Nova Scotia, B3S 0H6, Canada
Osaka Metropolitan University Hospital
RECRUITING

Osaka, 545-0051, Japan
Ospedale Santa Maria delle Croci
RECRUITING

Ravenna, Emilia-Romagna, 48121, Italy
Oulu University Hospital
RECRUITING

Oulu, 90220, Finland
Peking University Third Hospital
RECRUITING

Beijing, Beijing Municipality, 100091, China
Pindara Private Hospital
RECRUITING

Benowa, Queensland, 4217, Australia
Pratia Onkologia Katowice
ACTIVE_NOT_RECRUITING

Katowice, Silesian Voivodeship, 40-519, Poland
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
QEII Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Rabin Medical Center
RECRUITING

Petah Tikva, Central District, 4910021, Israel
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Kyǒnggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
Soroka Medical Center
RECRUITING

Beersheba, Southern District, 8410101, Israel
Sourasky Medical Center
RECRUITING

Tel Aviv, TELL ABĪB, 6423906, Israel
Southern Medical University Nanfang Hospital
RECRUITING

Guangzhou, Guangdong, 510515, China
St Vincent's Hospital Melbourne
RECRUITING

Fitzroy, Victoria, 3065, Australia
Städtisches Klinikum Braunschweig
RECRUITING

Braunschweig, 38114, Germany
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510555, China
Taichung Veterans General Hospital
RECRUITING

Taichung, 407, Taiwan
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06591, South Korea
The Catholic Univ. of Korea Seoul St. Mary's Hospital(Seoul St. Mary's Hospital)
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06591, South Korea
The Edmond and Lily Safra Children's Hospital; The Chaim Sheba Medical Center
RECRUITING

Ramat Gan, Central District, 5265601, Israel
The First Affiliated Hospital of Soochow University
RECRUITING

Suzhou, Jiangsu, 215006, China
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
The first Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310003, China
The first Affiliated hospital of Wenzhou medical University
RECRUITING

Wenzhou, Zhejiang, 325000, China
The first hospital of jilin university
RECRUITING

Changchun, Jilin, 130021, China
Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430030, China
Tongji University - Shanghai Fourth People's Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200434, China
Turku University Hospital
RECRUITING

Turku, Southwest Finland, 20520, Finland
Uniklinikum Salzburg
NOT_YET_RECRUITING

Salzburg, 5020, Austria
Universitaetsklinikum Tuebingen
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsklinikum Ulm
NOT_YET_RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
University Hospital of Ioannina
RECRUITING

Ioannina, Ípeiros, 455 00, Greece
University Hospital of Wales
NOT_YET_RECRUITING

Cardiff, CF14 4XW, United Kingdom
University of Fukui Hospital
RECRUITING

Yoshida-gun, Fukui, 910-1193, Japan
Universitätsmedizin Johannes Gutenberg Universität Mainz
RECRUITING

Mainz, Rhineland-Palatinate, 55131, Germany
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
ACTIVE_NOT_RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-367, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-214, Poland
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 12808, Czechia
Waikato Hospital
RECRUITING

Hamilton, Waikato Region, 3204, New Zealand
Yamagata University Hospital
RECRUITING

Yamagata, 990-9585, Japan

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