Experimental cocktail aims to outsmart resistant myeloma

NCT ID NCT05675449

Ongoing Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This early-stage trial tests two new drug combinations for people with multiple myeloma that has returned or stopped responding to treatment. One group gets elranatamab (an immune-boosting shot) plus carfilzomib and dexamethasone; the other gets elranatamab plus maplirpacept. The main goal is to check safety and find the right doses. About 59 participants will be treated for up to 2 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elranatamab (a drug that helps the immune system attack cancer cells) combined with either carfilzomib plus dexamethasone or maplirpacept
What this could lead to: If successful, this could point toward new combination treatments for multiple myeloma that has come back or stopped responding to other therapies.
What could go wrong: This is a very early (Phase 1) study with only 59 people, focused on safety and dosing—not yet on effectiveness. The combinations may cause side effects or fail to work better than existing options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Beverly Hills Cancer Center

Beverly Hills, California, 90211, United States
Clinical Research Advisors (Encino Satellite Location)

Encino, California, 91316, United States
Clinical Research Advisors (Korea Town Satellite Location)

Los Angeles, California, 90020, United States
Clinical Research Advisors (West Hollywood Satellite Location)

Los Angeles, California, 90048, United States
Dana Farber/Mass General Brigham Cancer Care, Inc

Boston, Massachusetts, 02115, United States
Division of Hematology Hadassah Medical Center - Ein Kerem

Jerusalem, 9112001, Israel
Emory University Administration Office

Atlanta, Georgia, 30322, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Griffin Cancer Research Building (GCRB)

Miami, Florida, 33136, United States
Hematology Division Davidoff Center, Rabin Medical Center, Beilinson Hospital

Petah Tikva, 4941492, Israel
Henry-Joyce Cancer Clinic

Nashville, Tennessee, 37232, United States
Johns Hopkins University Cancer Immunology/GI Oncology

Baltimore, Maryland, 21287, United States
MSK Monmouth

Middletown, New Jersey, 07748, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).

New York, New York, 10021, United States
Memorial Sloan Kettering Cancer Center - Main Campus

New York, New York, 10065, United States
Oncology Investigational Drug Service,Department of Pharmacy Services

Baltimore, Maryland, 21231, United States
Rabin Medical Center

Petah Tikva, 4941492, Israel
Rambam Health Care Campus

Haifa, 3109601, Israel
State University of Iowa, Division of Sponsored Programs

Iowa City, Iowa, 52242, United States
Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
Sylvester Comprehensive Cancer Center - Aventura

Aventura, Florida, 33180, United States
Sylvester Comprehensive Cancer Center - Coral Springs

Coral Springs, Florida, 33065, United States
Sylvester Comprehensive Cancer Center - Hollywood

Hollywood, Florida, 33021, United States
Sylvester Comprehensive Cancer Center - Kendall

Miami, Florida, 33176, United States
Sylvester Comprehensive Cancer Center - Plantation

Plantation, Florida, 33324, United States
Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical Center

Coral Gables, Florida, 33146, United States
The Research Fund of Hadassah Medical Organization (R.A.)

Jerusalem, 9112001, Israel
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, 21231, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Miami Hospital and Clinics

Miami, Florida, 33136, United States
University of Miami Hospital and Clinics - Deerfield Beach

Deerfield Beach, Florida, 33442, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Winship Cancer Institute

Atlanta, Georgia, 30322, United States

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