Pfizer tests new drug cocktail for Hard-to-Treat myeloma
NCT ID NCT05090566
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested elranatamab, a bispecific antibody that helps the immune system attack cancer cells, in combination with other drugs for people with multiple myeloma that had stopped responding to at least three prior treatments. The trial aimed to find the safest dose and see if the combinations could shrink tumors. However, the study was terminated early after enrolling 46 participants, so the full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Elranatamab (a bispecific antibody) combined with either nirogacestat or lenalidomide plus dexamethasone
What this could lead to
If successful, this could point toward a new combination treatment for multiple myeloma that has stopped responding to standard therapies.
What could go wrong
The trial was terminated early with only 46 participants, so results are limited. It is still early-stage research, and the combinations may not prove safe or effective in larger studies.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2, Canada
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Banner Gateway Medical Center
Gilbert, Arizona, 85234, United States
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Banner Gateway Medical Pavilion
Gilbert, Arizona, 85234, United States
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Banner Health d.b.a. Banner MD Anderson Cancer Center
Phoenix, Arizona, 85012, United States
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Beverly Hills Cancer Center
Beverly Hills, California, 90211, United States
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Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
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Cedars Sinai Medical Center Oncology IDS Pharmacy Attn:Suwicha Limvorasak ,PharmaD
Los Angeles, California, 90048, United States
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Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute (SOCCI)
Los Angeles, California, 90048, United States
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Cedars-Sinai Tarzana
Tarzana, California, 91356, United States
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Clinical Research Advisors
Encino, California, 91316, United States
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Clinical Research Advisors
Los Angeles, California, 90020, United States
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Clinical Research Advisors
Los Angeles, California, 90048, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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OIDS, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231, United States
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
Coral Gables, Florida, 33146, United States
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Sylvester Comprehensive Cancer Center- Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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The Johns Hopkins University School of Medicine
Baltimore, Maryland, 21205, United States
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The Ottawa Hospital - General Campus
Ottawa, Ontario, K1H 8L6, Canada
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The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (Also Imaging Facility)
Baltimore, Maryland, 21231, United States
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UHealth Tower
Miami, Florida, 33136, United States
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University of Miami
Coral Gables, Florida, 33146, United States