New monitoring method may help chest trauma patients breathe easier and leave the ventilator sooner
NCT ID NCT07432048
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new way to guide breathing treatments for people with severe blunt chest trauma (like from a car crash). Doctors will use a non-invasive monitoring technique called EIT to guide oscillation and lung expansion therapy. The goal is to improve oxygen levels, reduce time on a breathing machine, and lower the risk of lung infections. The study will include 80 adults aged 18-70 who are already on a ventilator.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
the cohort will be selected from a tertiary hospital
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Severe blunt chest trauma, defined as injury caused by blunt force such as chest impact or compression, with an Abbreviated Injury Scale (AIS) score of the chest ≥ 3 * Age 18 to 70 years * Time from injury to enrollment \< 48 hours * Receiving invasive mechanical ventilation, with duration of mechanical ventilation \< 24 hours * Written informed consent signed by the patient or his/her legal representative Exclusion Criteria: * Combined penetrating chest trauma * Perinatal women * Inability of the patient to cooperate with examinations and treatment * Contraindications to EIT monitoring, including implanted cardiac pacemaker, unhealed local skin wound after thoracic surgery, extensive subcutaneous emphysema of the chest, etc * Contraindications to OLE therapy: Hemodynamic instability (heart rate \< 60 beats/min or \> 130 beats/min; systolic blood pressure \< 90 mmHg or \> 180 mmHg; or mean arterial pressure \< 60 mmHg or \> 100 mmHg) * Unstable angina pectoris or cardiac arrhythmia * Intracranial pressure \> 20 mmHg * Active bleeding * Suspected or active hemoptysis * Undrained pneumothorax * Unstable deep vein thrombosis or pulmonary embolism * Unstable spinal or long bone fractures * Unstable head and neck injury
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How to take part
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The official record
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