Major trial aims to halt progression of scarred livers

NCT ID NCT06528314

Recruiting now Disease control Sponsor: Akero Therapeutics, Inc Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether a drug called efruxifermin can slow down or reverse liver damage in people who already have significant scarring (cirrhosis) from fatty liver disease (NASH/MASH). About 1,150 participants will receive either the drug or a placebo to see if it delays serious liver complications and improves liver health. The main goal is to control the disease and prevent it from getting worse.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Akero Clinical Study Site
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Birmingham, Alabama, 35209, United States

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Dothan, Alabama, 36301, United States

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Chandler, Arizona, 85224, United States

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ACTIVE_NOT_RECRUITING

Flagstaff, Arizona, 86001, United States
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Peoria, Arizona, 85381, United States

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Scottsdale, Arizona, 85258, United States

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Tucson, Arizona, 85712, United States
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Tucson, Arizona, 85712, United States

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Tucson, Arizona, 85713, United States

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Tucson, Arizona, 85715, United States

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ACTIVE_NOT_RECRUITING

Conway, Arkansas, 72032, United States
Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Jonesboro, Arkansas, 72401, United States
Akero Clinical Study Site
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Little Rock, Arkansas, 72205, United States

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North Little Rock, Arkansas, 72117, United States

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Coronado, California, 92118, United States

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Escondido, California, 92025, United States

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Folsom, California, 95630, United States

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Lancaster, California, 93534, United States

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Long Beach, California, 90815, United States

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Los Angeles, California, 90048, United States

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Newport Beach, California, 92663, United States

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Orange, California, 92868, United States

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Pasadena, California, 91105, United States

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Redwood City, California, 94063, United States

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Sacramento, California, 95817, United States

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San Francisco, California, 94115, United States

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San Francisco, California, 94117, United States
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San Jose, California, 95116, United States

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Tarzana, California, 91356, United States

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Aurora, Colorado, 80045, United States

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Colorado Springs, Colorado, 80907, United States

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Englewood, Colorado, 80113, United States

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New Haven, Connecticut, 06511, United States

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Washington D.C., District of Columbia, 20422, United States

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Bradenton, Florida, 34208, United States

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Brandon, Florida, 33511, United States

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Cutler Bay, Florida, 33189, United States

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Doral, Florida, 33126, United States

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Fort Myers, Florida, 33912, United States

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Hialeah Gardens, Florida, 33016, United States

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Inverness, Florida, 34452, United States

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Lakewood Rch, Florida, 34211, United States

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Largo, Florida, 33777, United States

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Lehigh Acres, Florida, 33936, United States

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Margate, Florida, 33063, United States

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Miami, Florida, 33136, United States

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Miami, Florida, 33175, United States

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Miami Gardens, Florida, 33014, United States

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Naples, Florida, 34102, United States

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New Port Richey, Florida, 34653, United States

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Ocala, Florida, 34471, United States

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Orlando, Florida, 32806, United States
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Orlando, Florida, 32807, United States

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Pembroke Pines, Florida, 33027, United States

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Riverview, Florida, 33578, United States

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Sarasota, Florida, 34240, United States

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Temple Terrace, Florida, 33617, United States

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Venice, Florida, 34285, United States
Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Viera, Florida, 32940, United States
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Weston, Florida, 33331, United States

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Zephyrhills, Florida, 33542, United States

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Atlanta, Georgia, 30309, United States

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Gainesville, Georgia, 30501, United States

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Marietta, Georgia, 30060, United States

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Snellville, Georgia, 30078, United States
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Chicago, Illinois, 60611, United States

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Hammond, Indiana, 46324, United States

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Indianapolis, Indiana, 46202, United States

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South Bend, Indiana, 46635, United States

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West Des Moines, Iowa, 50265, United States

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Topeka, Kansas, 66606, United States

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Louisville, Kentucky, 40202, United States

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Bastrop, Louisiana, 71220, United States

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Covington, Louisiana, 70433, United States

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Houma, Louisiana, 70363, United States

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Lafayette, Louisiana, 70503, United States

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Marrero, Louisiana, 70072, United States

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Metairie, Louisiana, 70006, United States

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Shreveport, Louisiana, 71105, United States

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West Monroe, Louisiana, 71291, United States

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Baltimore, Maryland, 21202, United States

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Bethesda, Maryland, 20889-0004, United States

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South Dartmouth, Massachusetts, 02747, United States

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Clinton Township, Michigan, 48038, United States
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Novi, Michigan, 48377, United States

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Southfield, Michigan, 48075, United States

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Rochester, Minnesota, 55905, United States

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Flowood, Mississippi, 39232, United States

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Columbia, Missouri, 65201, United States

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Kansas City, Missouri, 64131, United States

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St Louis, Missouri, 63110, United States

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St Louis, Missouri, 63123, United States

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Las Vegas, Nevada, 89106, United States

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Jackson, New Jersey, 08527, United States

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Somers Point, New Jersey, 08244, United States

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Sparta, New Jersey, 07871, United States

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Buffalo, New York, 14203, United States

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Manhasset, New York, 11030, United States

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New York, New York, 10016, United States

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New York, New York, 10021, United States

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New York, New York, 10029, United States

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Rochester, New York, 14642, United States

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Chapel Hill, North Carolina, 27516, United States

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Charlotte, North Carolina, 28204, United States

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Charlotte, North Carolina, 28207, United States

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Durham, North Carolina, 27710, United States

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Fayetteville, North Carolina, 28304, United States

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Morehead City, North Carolina, 28557, United States

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Raleigh, North Carolina, 27612, United States

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Statesville, North Carolina, 28625, United States

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Akron, Ohio, 44320, United States

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Springboro, Ohio, 45066, United States

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Westlake, Ohio, 44145, United States

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Oklahoma City, Oklahoma, 73112, United States

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Hershey, Pennsylvania, 17033, United States

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Philadelphia, Pennsylvania, 19104, United States

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Philadelphia, Pennsylvania, 19107, United States

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Pittsburgh, Pennsylvania, 15213, United States

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Charleston, South Carolina, 29425, United States

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Columbia, South Carolina, 29204, United States

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Summerville, South Carolina, 29485, United States

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Clarksville, Tennessee, 37040, United States

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Hermitage, Tennessee, 37076, United States

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Nashville, Tennessee, 37211, United States

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Amarillo, Texas, 79106, United States
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Austin, Texas, 78745, United States

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Austin, Texas, 78757, United States
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Austin, Texas, 78757, United States

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Bellaire, Texas, 77401, United States

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Brownsville, Texas, 78520, United States

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Corpus Christi, Texas, 78404, United States

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Dallas, Texas, 75203, United States

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Dallas, Texas, 75216, United States

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Dallas, Texas, 75234, United States

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Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75246, United States
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Dallas, Texas, 75390, United States

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Akero Clinical Study Site
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Denison, Texas, 75020, United States

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Edinburg, Texas, 78539, United States
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Edinburg, Texas, 78539, United States

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Fort Sam Houston, Texas, 78234, United States

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ACTIVE_NOT_RECRUITING

Fort Worth, Texas, 76104, United States
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ACTIVE_NOT_RECRUITING

Garland, Texas, 75044, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77030, United States
Akero Clinical Study Site
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Houston, Texas, 77030, United States

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Houston, Texas, 77074, United States

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Akero Clinical Study Site
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Houston, Texas, 77079, United States

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Pasadena, Texas, 77505, United States

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Pharr, Texas, 78577, United States
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San Antonio, Texas, 78222, United States

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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78229, United States

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San Antonio, Texas, 78251, United States

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ACTIVE_NOT_RECRUITING

Sugar Land, Texas, 77478, United States
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Sugar Land, Texas, 77478, United States

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Waco, Texas, 76710, United States

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Waco, Texas, 76712, United States

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Webster, Texas, 77598, United States

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Wichita Falls, Texas, 76301, United States

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Norfolk, Virginia, 23502, United States

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Richmond, Virginia, 23226-1925, United States

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Richmond, Virginia, 23236, United States

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Richmond, Virginia, 23249, United States

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Richmond, Virginia, 23284, United States

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Roanoke, Virginia, 24014, United States

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Seattle, Washington, 98105, United States

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Madison, Wisconsin, 53705, United States

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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1056ABI, Argentina

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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina

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La Plata, Buenos Aires, B1902AWL, Argentina

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Ramos Mejía, Buenos Aires, B1704ETD, Argentina

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Buenos Aires, Distrito Federal, C1406EEI, Argentina
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Rosario, Sante Fe, S2002KDT, Argentina

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Buenos Aires, C1180AAX, Argentina

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Broadmeadow, New South Wales, 2292, Australia

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Liverpool, New South Wales, 1871, Australia

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Westmead, New South Wales, 2145, Australia

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Herston, Queensland, 4029, Australia

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Adelaide, South Australia, 5000, Australia

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Box Hill, Victoria, 3128, Australia

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Clayton, Victoria, 3168, Australia

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Epping, Victoria, 3076, Australia

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Heidelberg, Victoria, 3084, Australia

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Melbourne, Victoria, 3004, Australia

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Murdoch, Western Australia, 6150, Australia

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Nedlands, Western Australia, 6009, Australia

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Perth, Western Australia, 6000, Australia

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Brasília, Federal District, 71681-603, Brazil
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Goiânia, Goiás, 74690-900, Brazil

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Belo Horizonte, Minas Gerais, 30220-140, Brazil

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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

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Edmonton, Alberta, T6G 2X8, Canada

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Toronto, Ontario, M5G 2C4, Canada

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Toronto, Ontario, M6H 3M1, Canada

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Vaughan, Ontario, L4L 4Y7, Canada

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Montreal, Quebec, H2X 0A9, Canada

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Terrebonne, Quebec, J7B6B7, Canada

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La Serena, Coquimbo Region, 1700000, Chile

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Las Condes, Santiago Metropolitan, 7500000, Chile

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Santiago, Santiago Metropolitan, 8320000, Chile

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Santiago, Santiago Metropolitan, 8330109, Chile

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Santiago, Santiago Metropolitan, 8380000, Chile
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Strasbourg, Bas-Rhin, 67200, France

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Limoges, Haute-Vienne, 87042, France

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Lille, Hauts-de-France, 59037, France

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Clichy, Hauts-de-Seine, 92118, France

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Vandœuvre-lès-Nancy, Lorraine, 54511, France

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Angers, Maine-et-Loire, 49933, France

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Toulouse, Occitanie, 31059, France

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Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France

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Montpellier Cedex 5, Provence-Alpes-Côte d'Azur Region, 34295, France

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Nice, Provence-Alpes-Côte d'Azur Region, 06202, France

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Lyon, Rhône, 69004, France

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Créteil, Val-de-Marne, 94010, France

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Le Chesnay, Île-de-France Region, 78150, France

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Paris, Île-de-France Region, 75013, France

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Frankfurt am Main, Hesse, 60590, Germany
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Homburg, Saarland, 66421, Germany

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Leipzig, Saxony, 04103, Germany
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Leipzig, Saxony, 04103, Germany

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Lübeck, Schleswig-Holstein, 23538, Germany

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Berlin, 13353, Germany

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Hyderabad, Andhra Pradesh, 500 082, India

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Surat, Gujarat, 395002, India
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Surat, Gujarat, 395009, India

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Vadodara, Gujarat, 390007, India

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Mysore, Karnataka, 570001, India

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Thiruvananthapuram, Kerala, 695011, India

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Mumbai, Maharashtra, 400008, India

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Mumbai, Maharashtra, 400012, India

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Nagpur, Maharashtra, 440010, India

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Pune, Maharashtra, 412201, India
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New Delhi, National Capital Territory of Delhi, 110 070, India

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New Delhi, National Capital Territory of Delhi, 110029, India

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New Delhi, National Capital Territory of Delhi, 110060, India

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Chandigarh, Punjab, 160012, India

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Ludhiana, Punjab, 141002, India

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Jaipur, Rajasthan, 302001, India
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Jaipur, Rajasthan, 302001, India

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Coimbatore, Tamil Nadu, 641005, India

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Hyderabad, Telangana, 500 004, India

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Varanasi, Uttar Pradesh, 221005, India
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Varanasi, Uttar Pradesh, 221005, India

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Rishikesh, Uttarakhand, 249203, India

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Kolkata, West Bengal, 700020, India
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Kolkata, West Bengal, 700020, India

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Kolkata, West Bengal, 700073, India

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Petah Tikva, Central District, 4941492, Israel
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Ramat Gan, Central District, 5265601, Israel

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Haifa, Haifa District, 3436212, Israel

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Afula, Northern District, 18101, Israel

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Nahariya, Northern District, 22100, Israel

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Haifa, 3109601, Israel

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Jerusalem, 9103102, Israel

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Jerusalem, 9112001, Israel

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Tel Aviv, 6423906, Israel

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Tel Aviv, 69710, Israel

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Foggia, Apulia, 71122, Italy

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San Giovanni Rotondo, Foggia, 71013, Italy

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Rozzano, Milan, 20089, Italy

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Torino, Turin, 10126, Italy

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Bologna, 40138, Italy

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Catania, 95100, Italy

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Messina, 98124, Italy

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Milan, 20122, Italy
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Milan, 20122, Italy

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Modena, 41124, Italy

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Novara, 28100, Italy

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Acapulco de Juárez, Guerrero, 39670, Mexico

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Guadalajara, Jalisco, 44130, Mexico

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Cuauhtémoc, Mexico City, 06700, Mexico

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Mexico City, Mexico City, 01376, Mexico

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Mérida, Yucatán, 97070, Mexico

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Benito Juárez, 3330, Mexico

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Mexico City, 14050, Mexico

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Poznan, Greater Poland Voivodeship, 61-293, Poland

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Krakow, Lesser Poland Voivodeship, 31-501, Poland

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Wroclaw, Lower Silesian Voivodeship, 50-381, Poland

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Wroclaw, Lower Silesian Voivodeship, 53-673, Poland

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Lodz, Lódzkie, 91-473, Poland

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Warsaw, Masovian Voivodeship, 00-215, Poland

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Warsaw, Masovian Voivodeship, 02-672, Poland

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Częstochowa, Silesian Voivodeship, 42-202, Poland

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Katowice, Silesian Voivodeship, 40-752, Poland

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Manatí, 00674, Puerto Rico

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Mayagüez, 00680, Puerto Rico

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San Juan, 00927, Puerto Rico

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Daegu, Daegu Gwang'yeogsi [Taegu-Kwangyokshi], 41944, South Korea

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Incheon, Gyeonggi-do, 22332, South Korea

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Goyang-si, Gyeonggido, 10444, South Korea

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Daegu, Gyeongsangbugdo [Kyongsangbuk-do], 42601, South Korea

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Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 03080, South Korea

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Seoul, Seoul Teugbyeolsi, 04763, South Korea

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Sabadell, Barcelona, 08208, Spain

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Santander, Cantabria, 39008, Spain

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Majadahonda, Madrid, 28222, Spain

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Barcelona, 08035, Spain

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Madrid, 28007, Spain

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Madrid, 28027, Spain

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Seville, 41013, Spain

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Valencia, 46010, Spain

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Valencia, 46015, Spain

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Lugano, Canton Ticino, 6900, Switzerland

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Bern, 3010, Switzerland

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Sankt Gallen, 9007, Switzerland

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Zurich, 8091, Switzerland

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Ankara, 06560, Turkey (Türkiye)

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Bursa, 16059, Turkey (Türkiye)

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Rize, 53020, Turkey (Türkiye)

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London, England, SE5 9RS, United Kingdom

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Nottingham, England, NG7 2UH, United Kingdom

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Birmingham, B15 2TH, United Kingdom

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London, NW3 2QG, United Kingdom

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London, SW10 9NH, United Kingdom

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Newcastle upon Tyne, NE7 7DN, United Kingdom

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Whitechapel, E1 1FR, United Kingdom

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Conditions

Explore the condition pages connected to this study.

MASH - METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS NASH - NONALCOHOLIC STEATOHEPATITIS