Nerve-Zapping procedure could boost liver cancer therapy
NCT ID NCT07187284
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether adding a nerve-zapping procedure called endovascular denervation (EDN) to standard liver cancer treatments (TACE/HAIC and immune-targeted drugs) can improve outcomes for people with advanced liver cancer that has spread to the portal vein and stopped responding to initial therapy. About 62 participants will be randomly assigned to receive either the combination or standard care alone. The goal is to see if the combo delays tumor growth and is safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Endovascular denervation (EDN) plus transarterial chemoembolization/hepatic arterial infusion chemotherapy (TACE/HAIC) and immune-targeted therapy
- What this could lead to
- If successful, this combination could offer a new treatment option for advanced liver cancer patients who have stopped responding to initial therapy, potentially improving tumor control and survival.
- What could go wrong
- This is an early Phase 1/2 trial with only 62 participants, so results are preliminary. The added nerve ablation procedure carries risks like bleeding or nerve damage, and the overall benefit over standard care is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HCC - HEPATOCELLULAR CARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhongda Hospital Affiliated to Southeast University, Department of Interventional and Vascular Surgery
Nanjing, Jiangsu, 210009, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new drug combo shrink liver tumors?
- Ancient herbal mix could boost liver health in advanced cancer
- Double immune attack: new drug combo takes on advanced liver cancer
- Breathing pure oxygen during an MRI may reveal whether liver cancer treatment is working
- Radiation and drug combo shows promise for tough liver cancers
- New immunotherapy combo aims to stop liver cancer return after surgery