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Sleep disorder may hold the key to spotting Parkinson's years earlier

NCT ID NCT07790744

Knowledge-focused Sponsor: Danish Research Centre for Magnetic Resonance Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This study looks at people with REM sleep behavior disorder (RBD), a condition where people act out their dreams and which often leads to Parkinson's disease. Researchers will use advanced brain imaging, sleep tests, and physical exams to compare 50 people with RBD to 50 healthy controls. The goal is to find early markers of Parkinson's, such as damage to specific brain areas, that could allow earlier diagnosis and treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
No drug or treatment is given. The study uses imaging and tests to observe early signs of Parkinson's disease.
What this could lead to
If successful, this could lead to earlier detection of Parkinson's disease, allowing treatments to start before symptoms fully develop.
What could go wrong
This is an observational study, so it will not test any treatment. The findings may not lead to a proven screening method, and the small number of participants limits how broadly the results can be applied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We have 2 groups; Subjects diagnosed with REM-sleep behaviour disorder via polysomnography Healthy, age- and gendermatched controls. Our RBD-group will be recruited via an ongoing cohort at a different site (Danish center for sleep medicine), where subjects diagnosed with RBD via polysomnography will be asked to also participate in our cohort, should they fulfill our inclusion criteria. Controls will be recruited via our own institutions webpage, as well as advertisements on other danish websites such as trialtree.dk.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Both groups - The ability to give informed consent For RBD-group * Verified REM-sleep behaviour disorder via polysonography * No other significant neurological and psychiatric ilness For Healthy controls \- Age matched to RBD-group Exclusion Criteria: * Ferrous objects in or around the body * Pacemaker or other implanted electronic devices * Drug abuse unrelated to medication or alcohol abuse over a period of 6 months prior to the experiment * Other major immunological, cardiac, neurological or neuropsychiatric disorders * Claustrophobia * Incapability of giving informed consent * Unwillingness to be informed about abnormal findings. * Participation in clinical trials involving drug testing over a period of 6 months prior to the experiment. * Disease symptoms leading to excessive movement inside the scanner (e.g., excessive tremor)

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 Parkinson disease REM sleep behavior disorder synucleinopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease (PD) Prodromal Parkinson's disease Rem sleep behavior disorder Synucleinopathies

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Danish Research Centre for Magnetic Resonance

    RECRUITING

    Hvidovre, 2650, Denmark

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