Cancer drug duvelisib tested to prevent lymphoma return after transplant

NCT ID NCT04331119

First seen Jan 05, 2026 · Last updated Jun 24, 2026 · Updated 31 times

Summary

This phase 2 trial tested the drug duvelisib (Copiktra) as a maintenance therapy after autologous stem cell transplant in 17 adults with T-cell lymphoma. The goal was to see if duvelisib is safe and helps keep the cancer from coming back. The study was terminated early, so results are limited.

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Contacts and locations

Locations

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

duvelisib (Copiktra)

What this could lead to

If it works, this could point toward a way to keep T-cell lymphoma from coming back after a stem cell transplant.

What could go wrong

This trial was terminated early with only 17 participants, so results are very limited. Duvelisib may cause side effects and may not improve survival.

Conditions

The condition(s) this trial relates to.

anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma peripheral T-cell lymphoma, not otherwise specified T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.