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New immunotherapy combo shows promise for stage IV lung cancer

NCT ID NCT03057106

Ongoing Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two immunotherapy drugs, durvalumab and tremelimumab, with or without chemotherapy, in 301 people with stage IV non-small cell lung cancer. The goal is to see if these drugs help patients live longer by helping their immune system fight the cancer. Participants must have a confirmed diagnosis and cannot have certain genetic mutations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer metastatic malignant neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER METASTATIC

Contacts and locations

Locations

  • Algoma District Cancer Program

    Sault Ste. Marie, Ontario, P6B 0A8, Canada

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, S4T 7T1, Canada

  • BCCA - Fraser Valley Cancer Centre

    Surrey, British Columbia, V3V 1Z2, Canada

  • BCCA - Vancouver Cancer Centre

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Ballarat Health Services

    Ballarat, Victoria, 3350, Australia

  • Border Medical Oncology

    Wodonga, Victoria, 3690, Australia

  • CHU de Quebec-Hopital l'Enfant-Jesus (HEJ)

    Québec, Quebec, G1J 1Z4, Canada

  • CHUM-Centre Hospitalier de l'Universite de Montreal

    Montreal, Quebec, H2X 3E4, Canada

  • Cambridge Memorial Hospital

    Cambridge, Ontario, N1R 3G2, Canada

  • Campbelltown Hospital

    Campbelltown, New South Wales, 2560, Australia

  • Centre hospitalier universitaire de Sherbrooke

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Coffs Habour Health Campus - NCCI

    Coffs Harbour, New South Wales, 2450, Australia

  • Concord Repatriation General Hospital

    Concord, New South Wales, 2139, Australia

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Epworth HealthCare - Richmond

    Richmond, Victoria, 3121, Australia

  • Gold Coast University Hospital

    Southport, Queensland, 4215, Australia

  • Grand River Regional Cancer Centre

    Kitchener, Ontario, N2G 1G3, Canada

  • Health Sciences North

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • Hopital de la Cite-de-la-Sante

    Laval, Quebec, H7M 3L9, Canada

  • Horizon Health Network

    Fredericton, New Brunswick, E3B 5N5, Canada

  • Humber River Regional Hospital

    Toronto, Ontario, M3M 0B2, Canada

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, L8V 5C2, Canada

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7, Canada

  • Liverpool Cancer Therapy Centre, Liverpool Hospital

    Liverpool, New South Wales, 2170, Australia

  • Mater Research Institute South Brisbane

    South Brisbane, Queensland, 4101, Australia

  • Michael Garron Hospital

    Toronto, Ontario, M4C 3E7, Canada

  • Nepean Hospital

    Kingswood, New South Wales, 2751, Australia

  • Niagara Health System

    St. Catharines, Ontario, L2S 0A9, Canada

  • North York General Hospital

    Toronto, Ontario, M2K 1E1, Canada

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 8L6, Canada

  • PEI Cancer Treatment Centre

    Charlottetown, Prince Edward Island, C1A 8T5, Canada

  • Prince of Wales Hospital

    Randwick, New South Wales, 2031, Australia

  • Princess Alexandra Hospital

    Brisbane, Queensland, 4102, Australia

  • Regional Health Authority B, Zone 2

    Saint John, New Brunswick, E2L 4L2, Canada

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000, Australia

  • Saint John of God Hospital Subiaco

    Subiaco, Western Australia, 6008, Australia

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • St. George Hospital, Cancer Care Centre

    Kogarah, New South Wales, 2217, Australia

  • St. Vincent's Hospital

    Victoria Park, 3065, Australia

  • Stronach Regional Health Centre at Southlake

    Newmarket, Ontario, L3Y 2P9, Canada

  • The Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • The Moncton Hospital

    Moncton, New Brunswick, E1C 6Z8, Canada

  • The Prince Charles Hospital

    Chermside, Queensland, 4032, Australia

  • The Tweed Hospital

    Lismore, New South Wales, 2480, Australia

  • The Vitalite Health Network - Dr. Leon Richard

    Moncton, New Brunswick, E1C 8X3, Canada

  • Toowoomba Hospital

    Toowoomba, Queensland, 4350, Australia

  • University Health Network

    Toronto, Ontario, M5G 2M9, Canada

  • University Institute of Cardiology and

    Québec, Quebec, G1V 4G5, Canada

  • Windsor Regional Cancer Centre

    Windsor, Ontario, N8W 2X3, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.