New immunotherapy combo aims to fight advanced liver cancer

NCT ID NCT03298451

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 study tests whether combining two immunotherapy drugs, durvalumab and tremelimumab, helps people with advanced liver cancer live longer than the current standard drug sorafenib. About 1,300 participants who have not had prior systemic therapy are being enrolled. The study compares the combination, durvalumab alone, and sorafenib.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Durvalumab and tremelimumab (immunotherapy drugs)
What this could lead to: If successful, this combination could offer a new first-line treatment option for advanced liver cancer, potentially improving survival compared to current standard therapy.
What could go wrong: This is a large Phase 3 trial, but results may not show a significant survival benefit over sorafenib. Immunotherapy can cause immune-related side effects.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA

Contacts and locations

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Locations

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Los Angeles, California, 90048, United States
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Orange, California, 92868, United States
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San Francisco, California, 94158, United States
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Washington D.C., District of Columbia, 20007, United States
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Fort Myers, Florida, 33916, United States
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Jacksonville, Florida, 32224, United States
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Westwood, Kansas, 66205, United States
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Baltimore, Maryland, 21231, United States
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Ann Arbor, Michigan, 48109, United States
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Rochester, Minnesota, 55905, United States
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New York, New York, 10065, United States
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Charlotte, North Carolina, 28262, United States
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Portland, Oregon, 97213, United States
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Pittsburgh, Pennsylvania, 15237, United States
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Dallas, Texas, 74235, United States
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Dallas, Texas, 75216, United States
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Dallas, Texas, 75235, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77090, United States
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Murray, Utah, 84107, United States
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Barretos, Brazil
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Curitiba, Brazil
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Florianópolis, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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São Paulo, Brazil
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Calgary, Alberta, T2N 4N2, Canada
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Edmonton, Alberta, T6G 1Z2, Canada
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Hamilton, Ontario, L8V 5C2, Canada
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Kingston, Ontario, K7L 2V7, Canada
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London, Ontario, N6A 4L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Québec, Quebec, G1R 2J6, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Beijing, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Dalian, China
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Fuzhou, China
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Guangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Nanchang, China
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Nanjing, China
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Nanning, China
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Shanghai, China
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Suzhou, China
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Wuhan, China
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Xi'an, China
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Zhengzhou, China
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Clichy, France
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Lille, France
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Marseille, France
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Montpellier, France
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Nancy, France
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Nantes, France
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Nice, France
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Pessac, France
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Poitiers, France
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Reims, France
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Rouen, France
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Saint-Etienne, France
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Toulouse, France
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Villejuif, France
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Aachen, Germany
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Cologne, Germany
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Essen, Germany
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Hanover, Germany
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Heidelberg, Germany
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Leipzig, Germany
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Mainz, Germany
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München, Germany
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Tübingen, Germany
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Ulm, Germany
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Hong Kong, Hong Kong
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Bangalore, India
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Bhubneshwar, India
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Chennai, India
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Hubli, India
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Hyderabad, India
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Karmsad, India
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Mumbai, India
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Nashik, India
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New Delhi, India
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Benevento, Italy
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Meldola, Italy
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Milan, Italy
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Naples, Italy
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Perugia, Italy
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Pisa, Italy
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Roma, Italy
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Rozzano, Italy
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Bunkyoku, Japan
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Chiba, Japan
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Fukuoka, Japan
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Hiroshima, Japan
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Iizuka, Japan
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Kanazawa, Japan
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Kōtoku, Japan
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Kumamoto, Japan
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Kurume, Japan
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Matsuyama, Japan
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Mitakashi, Japan
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Musashino, Japan
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Nagoya, Japan
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Okayama, Japan
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Osaka, Japan
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Ōgaki, Japan
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Ōsaka-sayama, Japan
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Saga, Japan
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Sapporo, Japan
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Shiwa, Japan
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Suntogun, Japan
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Tsu, Japan
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Yokohama, Japan
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Moscow, Russia
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Murmansk, Russia
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Nizhny Novgorod, Russia
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Novosibirsk, Russia
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Obninsk, Russia
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Omsk, Russia
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Saint Petersburg, Russia
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Ufa, Russia
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Ilsan, Gyeonggi-do, 10408, South Korea
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Seongnam-si, Gyeonggi-do, 13620, South Korea
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Busan, 49241, South Korea
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Daegu, 41944, South Korea
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Seoul, 3080, South Korea
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Seoul, 3722, South Korea
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Seoul, 5505, South Korea
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Seoul, 6351, South Korea
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Barcelona, Spain
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Madrid, Spain
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Oviedo, Spain
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Pamplona Madrid, Spain
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Santander, Spain
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Chiayi City, Taiwan
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Chang Mai, Thailand
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Khon Kaen, Thailand
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Phitsanulok, Thailand
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Songkhla, Thailand
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Dnipro, Ukraine
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IvanoFrankivsk, Ukraine
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Kharkiv, Ukraine
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Kropyvnitskyi, Ukraine
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Kyiv, Ukraine
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Lviv, Ukraine
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Odesa, Ukraine
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Uzhhorod, Ukraine
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Hanoi, Vietnam
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Hochiminh, Vietnam

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