Immunotherapy combo shows promise in bile duct cancer trial

NCT ID NCT03875235

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether adding the immunotherapy drug durvalumab to standard chemotherapy (gemcitabine plus cisplatin) helps people with advanced biliary tract cancer live longer. About 810 participants received either durvalumab or a placebo alongside chemo. The study measures overall survival and how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

durvalumab (an immunotherapy drug) combined with gemcitabine and cisplatin (chemotherapy)

What this could lead to

If it works, this could offer a new first-line treatment option that helps people with advanced biliary tract cancer live longer.

What could go wrong

This is a late-stage trial, but results are not yet final. The added benefit of durvalumab may be modest, and immunotherapy can cause immune-related side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer biliary tract neoplasm Biliary Tract Neoplasms cholangiocarcinoma gallbladder carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT NEOPLASMS

Contacts and locations

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Locations

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Los Angeles, California, 90027, United States
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Orange, California, 92868, United States
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Washington D.C., District of Columbia, 20007, United States
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Fort Myers, Florida, 33905, United States
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St. Petersburg, Florida, 33705, United States
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Westwood, Kansas, 66205, United States
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Louisville, Kentucky, 40202, United States
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Burlington, Massachusetts, 01805, United States
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St Louis, Missouri, 63110, United States
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Chapel Hill, North Carolina, 27514, United States
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Portland, Oregon, 97213, United States
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Philadelphia, Pennsylvania, 19111, United States
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Chattanooga, Tennessee, 37404, United States
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Nashville, Tennessee, 37203, United States
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Seattle, Washington, 98109, United States
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Buenos Aires, C1118AAT, Argentina
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CABA, C1012AAR, Argentina
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CABA, C1019ABS, Argentina
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Ciudad de Buenos Aires, 1280, Argentina
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Ciudad de Buenos Aires, C1426ANZ, Argentina
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Rosario, 2000, Argentina
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San Salvador de Jujuy, 4600, Argentina
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Burgas, 8000, Bulgaria
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Sofia, 1330, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1606, Bulgaria
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Varna, 9010, Bulgaria
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Santiago, 7630370, Chile
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Temuco, 4810218, Chile
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Baoding, 071000, China
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Beijing, 100021, China
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Beijing, 100142, China
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Bengbu, 233004, China
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Chongqing, 400038, China
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Foshan, 528000, China
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Guangzhou, 510062, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Harbin, 150081, China
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Hefei, 230001, China
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Hefei, 230601, China
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Jinan, 250014, China
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Nanchang, 330006, China
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Nanjing, 210002, China
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Shandong, China
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Shanghai, 200032, China
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Shenyang, 100003, China
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Suzhou, 215004, China
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Xi'an, 710061, China
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Zhengzhou, 450008, China
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Zhuhai, 519000, China
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Clichy, 92210, France
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Dijon, 21079, France
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Montpellier, 34295, France
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Nice, 6189, France
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Paris, 75571, France
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Pessac, 33604, France
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Poitiers, 86021, France
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Hong Kong, 00000, Hong Kong
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Hong Kong, 150001, Hong Kong
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Hong Kong, Hong Kong
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Kowloon, Hong Kong
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Gurgaon, 122001, India
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Kolkata, 700160, India
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Mumbai, 400012, India
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New Delhi, 110085, India
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Faenza, 48018, Italy
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Florence, 50134, Italy
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Milan, 20132, Italy
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Naples, 80131, Italy
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Roma, 00168, Italy
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Verona, 37134, Italy
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Chūōku, 104-0045, Japan
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Kashiwa, 227-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Mitaka-shi, 181-8611, Japan
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Osaka, 541-8567, Japan
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Suita-shi, 565-0871, Japan
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Wakayama, 641-8510, Japan
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Yokohama, 241-8515, Japan
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Gdansk, 80-952, Poland
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Lodz, 93-513, Poland
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Olsztyn, 10-228, Poland
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Poznan, 60-780, Poland
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Warsaw, 02-106, Poland
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Wroclaw, 50-556, Poland
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Barnaul, 656049, Russia
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Kostroma, 156005, Russia
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Moscow, 115478, Russia
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Moscow, 121467, Russia
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Moscow, 125284, Russia
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Omsk, 644033, Russia
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Saint Petersburg, 197022, Russia
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Saint Petersburg, 197758, Russia
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 152-703, South Korea
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Chiayi City, 613, Taiwan
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Kaohsiung City, 82445, Taiwan
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Kaohsiung City, 83301, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10050, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 50200, Thailand
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Si Sa Ket, 33000, Thailand
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Ankara, 06100, Turkey (Türkiye)
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Istanbul, 34030, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Mersin, 33110, Turkey (Türkiye)
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Bristol, BS2 8ED, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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London, NW3 2QG, United Kingdom
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London, W12 0NN, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Oxford, OX3 7LE, United Kingdom
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Romford, RM7 0AG, United Kingdom
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Sheffield, S10 2SJ, United Kingdom