Could stem cells be the key to managing heart failure?

NCT ID NCT02032004

Completed Disease control Sponsor: Mesoblast, Inc. Source: ClinicalTrials.gov ↗

First seen Apr 08, 2026 · Last updated May 17, 2026 · Updated 5 times

Summary

This study tested a stem cell treatment (rexlemestrocel-L) in 565 adults with chronic heart failure. The goal was to see if injecting these cells into the heart could reduce serious heart events like hospitalizations or death. Participants were randomly assigned to receive either the stem cells or a sham procedure, and researchers tracked their health over time.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Mesoblast Investigational Site 10754 - University of California, San Diego

La Jolla, California, 92037, United States
Mesoblast Investigational Site 10755 - Texas Heart Institute

Houston, Texas, 77030, United States
Mesoblast Investigational Site 10756 - Mayo Clinic

Phoenix, Arizona, 85054, United States
Mesoblast Investigational Site 10757 - Cardiology, P.C.

Birmingham, Alabama, 35211, United States
Mesoblast Investigational Site 10758 - The Christ Hospital

Cincinnati, Ohio, 45219, United States
Mesoblast Investigational Site 10759 - Scripps Clinic

La Jolla, California, 92037, United States
Mesoblast Investigational Site 10760 - Shands Hospital, University of Florida

Gainesville, Florida, 32610, United States
Mesoblast Investigational Site 10761 - Mayo Clinic

Rochester, Minnesota, 55905, United States
Mesoblast Investigational Site 10762 - Minneapolis Heart Institute

Minneapolis, Minnesota, 55407, United States
Mesoblast Investigational Site 10763 - University Hospital

Salt Lake City, Utah, 84132, United States
Mesoblast Investigational Site 10764 - University of Wisconsin

Madison, Wisconsin, 53792, United States
Mesoblast Investigational Site 10765 - Georgia Regents University

Augusta, Georgia, 30912, United States
Mesoblast Investigational Site 10766 - Michigan Cardiovascular Institute

Saginaw, Michigan, 48602, United States
Mesoblast Investigational Site 10767 - Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
Mesoblast Investigational Site 10768 - University of Miami

Miami, Florida, 33215, United States
Mesoblast Investigational Site 10769 - Aurora Healthcare

Milwaukee, Wisconsin, 53215, United States
Mesoblast Investigational Site 10770 - University of Cincinnati

Cincinnati, Ohio, 45267, United States
Mesoblast Investigational Site 10771 - Heart & Vascular Research, Swedish Medical Center

Seattle, Washington, 98122, United States
Mesoblast Investigational Site 10772 - University Cardiologist, Rush University Medical Center

Chicago, Illinois, 60612, United States
Mesoblast Investigational Site 10773

Cleveland, Ohio, United States
Mesoblast Investigational Site 10774 - University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States
Mesoblast Investigational Site 10775 - Cedars-Sinai Medical Care Foundation

Los Angeles, California, 90211, United States
Mesoblast Investigational Site 10776 - Columbia University Medical Center

New York, New York, 10032, United States
Mesoblast Investigational Site 10777 - Stern Cardiovascular Foundation

Germantown, Tennessee, 38125, United States
Mesoblast Investigational Site 10778 - Orange County Cardiology

Orange, California, 92868, United States
Mesoblast Investigational Site 10779 - Mercy Gilbert Medical Center

Gilbert, Arizona, 85297, United States
Mesoblast Investigational Site 10780 - Morton Plant Hospital

Clearwater, Florida, 33756, United States
Mesoblast Investigational Site 10781 - Duke University

Durham, North Carolina, 27710, United States
Mesoblast Investigational Site 10782

Boston, Massachusetts, United States
Mesoblast Investigational Site 10783 - Gill Heart Institute, University of Kentucky

Lexington, Kentucky, 40536, United States
Mesoblast Investigational Site 10785 - Lehigh Valley Hospital

Allentown, Pennsylvania, 18103, United States
Mesoblast Investigational Site 10786 - Cardiovascular Associates of Mesa

Mesa, Arizona, 85206, United States
Mesoblast Investigational Site 10789 - Aspirus Research Institute

Wausau, Wisconsin, 54401, United States
Mesoblast Investigational Site 11024 - Victoria Heart Institute Foundation

Victoria, British Columbia, V8R 4R2, Canada
Mesoblast Investigational Site 11025 - St. Michael's Hospital

Toronto, Ontario, M5B 1W8, Canada
Mesoblast Investigational Site 11027

Edmonton, Alberta, Canada
Mesoblast Investigational Site 13022 - University of Louisville

Louisville, Kentucky, 40202, United States
Mesoblast Investigational Site 13023 - University of Arizona Medical Center

Tucson, Arizona, 85724, United States
Mesoblast Investigational Site 13024 - Austin Heart, PLLC

Austin, Texas, 78756, United States
Mesoblast Investigational Site 13026 - Sanger Heart and Vascular Institute, Carolinas Healthcare System

Charlotte, North Carolina, 28203, United States
Mesoblast Investigational Site 13027 - Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Mesoblast Investigational Site 13030 - University of Iowa

Iowa City, Iowa, 52242, United States
Mesoblast Investigational Site 13031 - St. John's Regional Medical Center

Oxnard, California, 93030, United States
Mesoblast Investigational Site 13261 - University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Mesoblast Investigational Site 13262 - University of Alabama at Birmingham Hospital

Birmingham, Alabama, 35233, United States
Mesoblast Investigational Site 13263 - RWJ Barnabas Heart Center

Newark, New Jersey, 07112, United States
Mesoblast Investigational Site 13264 - Florida Hospital Pepin Heart Institute

Tampa, Florida, 33613, United States
Mesoblast Investigational Site 13265 - University of California, Los Angeles

Los Angeles, California, 90045, United States
Mesoblast Investigational Site 13266

New Orleans, Louisiana, United States
Mesoblast Investigational Site 13267 - Bethesda Heart Hospital

Boynton Beach, Florida, 33435, United States
Mesoblast Investigational Site 13268 - Houston Methodist Hospital

Houston, Texas, 77030, United States
Mesoblast Investigational Site 13273 - University of Florida Health

Jacksonville, Florida, 32209, United States
Mesoblast Investigational Site 13274 - Soltero CV Research Center, Baylor Scott & White Research Institute

Dallas, Texas, 75226, United States
Mesoblast Investigational Site 13275 - Stanford University Hospital

Stanford, California, 94305, United States
Mesoblast Investigational Site 13277

Philadelphia, Pennsylvania, United States
Mesoblast Investigational Site 13278 - OhioHealth Research Institute

Columbus, Ohio, 43214, United States
Mesoblast Investigational Site 13279

Milwaukee, Wisconsin, United States
Mesoblast Investigational Site 13280

Orlando, Florida, United States
Mesoblast Investigational Site 13281

Las Vegas, Nevada, United States

Conditions

Explore the condition pages connected to this study.

CHRONIC HEART FAILURE