Parkinson's drug shows promise for depression in seniors

NCT ID NCT04469959

First seen Feb 06, 2026 · Last updated Apr 25, 2026 · Updated 12 times

Summary

This study tests whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers believe that depression in later life may be linked to a drop in dopamine, a brain chemical that affects movement and motivation. About 100 people aged 60 and older with depression and slow thinking or walking will receive levodopa to see if it helps.

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Contacts and locations

Locations

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • Vanderbilt Psychiatric Hospital

    Nashville, Tennessee, 37212, United States

Conditions

Explore the condition pages connected to this study.