Could a simple antibiotic shot slash infection risk in open fractures?
NCT ID NCT04964947
First seen May 18, 2026 · Last updated May 30, 2026 · Updated 2 times
Summary
This study tests whether adding a local injection of the antibiotic tobramycin directly into the wound, alongside standard IV antibiotics, can lower the chance of infection after open fracture surgery. Open fractures have a high risk of infection because blood flow to the injured area is often poor. The trial involves 600 adults with open fractures of the arm or leg and will track infection rates for one year after surgery.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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University of Kentucky
Lexington, Kentucky, 40536, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Conditions
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