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New study tests safer blood thinners for Clot-Prone patients

NCT ID NCT07372170

Recruiting now Knowledge-focused Sponsor: Infanta Leonor University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two types of blood thinners—direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs)—to see which works better at preventing repeat blood clots in people with a low-risk form of antiphospholipid syndrome (APS). APS is an autoimmune condition that raises the risk of dangerous clots. Researchers will follow 600 adults already taking one of these medications in routine care, tracking clot recurrences and bleeding events. The goal is to provide real-world evidence on whether newer DOACs are a safe option for these patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs)
What this could lead to
If successful, this study could clarify whether DOACs are a safe and effective alternative to standard blood thinners for preventing repeat clots in low-risk antiphospholipid syndrome patients.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by patient selection or other factors. It cannot prove cause and effect, and findings may not apply to higher-risk patients.

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Conditions

The condition(s) this trial relates to.

antiphospholipid syndrome thrombophilia thrombophilia due to thrombin defect Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIPHOSPHOLIPID SYNDROME (APS) THROMBOPHILIA VENOUS THROMBOSIS (DISORDER)

Contacts and locations

Locations

  • Hospital Universitario Infanta Leonor

    RECRUITING

    Madrid, Madrid, 28031, Spain

  • Hospital Universitario Infanta Sofía

    RECRUITING

    Madrid, Madrid, Spain

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