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Can a simple checklist cut unnecessary antibiotics for diverticulitis?

NCT ID NCT07824180

Disease control Sponsor: Ente Ospedaliero Cantonale, Bellinzona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Acute uncomplicated diverticulitis is often treated with antibiotics, but evidence suggests they are not always needed. This study evaluates whether a standardized treatment approach based on clinical findings, lab results, other health conditions, and CT scans can reduce unnecessary antibiotic use without increasing treatment failure. Researchers compare patients treated before and after the approach is introduced at Swiss hospitals, following them for up to 24 months to track antibiotic use, hospital admissions, complications, and recurrence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a standardized treatment algorithm that decides antibiotic use based on clinical, lab, and CT findings
What this could lead to
If the algorithm works, hospitals could safely give fewer antibiotics to people with mild diverticulitis, sparing them side effects and helping curb antibiotic resistance.
What could go wrong
This is a before-and-after study, not a randomized trial, so other changes over time could explain the results. Skipping antibiotics may fail for some patients, and the study tracks treatment failure, complications, and recurrence for up to 24 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 800 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * CT-confirmirmed acute uncomplicated diverticulitis of the left colon * Ability to provide informed consent for participants in the prospective phase Exclusion Criteria: * Complicated acute diverticulitis, defined as diverticulitis with abscess, perforation (free air), fistula, or distant free fluid * Diverticulitis of the right or transverse colon -.Alternative diagnosis explaining the participant's symptoms * No possibility of completing the 90-day follow-up * Inability to provide informed consent for the prospective phase

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Conditions

The condition(s) this trial relates to.

diverticulitis diverticulitis of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diverticulitis

How to take part

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  1. The official record

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  2. A doctor treating you

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