New targeted combo aims to outdo chemo for KRAS lung cancer

NCT ID NCT06793215

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 23 times

Summary

This study tests whether a new targeted drug (divarasib) plus an immunotherapy (pembrolizumab) works better than standard chemotherapy plus immunotherapy for people with a specific genetic mutation (KRAS G12C) in advanced non-small cell lung cancer. About 600 adults who have not had prior treatment for advanced disease will take part. The main goals are to see if the new combo delays cancer growth and helps people live longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

A.O. Universitaria Policlinico Di Modena
RECRUITING

Modena, Emilia-Romagna, 41100, Italy
AORN Ospedali dei Colli Ospedale Monaldi
RECRUITING

Naples, Campania, 80131, Italy
ARKE Estudios Clínicos S.A. de C.V.
RECRUITING

Mexico City, 06700, Mexico
AZ Delta (Campus Rumbeke)
RECRUITING

Roeselare, 8800, Belgium
AZORG Campus Aalst-Moorselbaan
RECRUITING

Aalst, 9300, Belgium
Aarhus Universitetshospital
RECRUITING

Aarhus N, 8200, Denmark
Affiliated Oncologists, LLC
RECRUITING

Chicago Ridge, Illinois, 60415, United States
Ag. Loukas Hospital
RECRUITING

Thessaloniki, 55236, Greece
Alaska Oncology and Hematology
RECRUITING

Anchorage, Alaska, 99508, United States
Alexandras Hospital
RECRUITING

Athens, 115 28, Greece
Amphia Ziekenhuis
RECRUITING

Breda, 4818 CK, Netherlands
Ascension Sacred Heart
RECRUITING

Pensacola, Florida, 32504, United States
Asklepios Fachkliniken GmbH
RECRUITING

Gauting, 82131, Germany
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera San Camillo Forlanini
RECRUITING

Rome, Lazio, 00151, Italy
Azienda Ospedaliera San Gerardo di Monza
RECRUITING

Monza MI, Lombardy, 20900, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)
RECRUITING

Milan, Lombardy, 20162, Italy
BC Cancer - Victoria
RECRUITING

Victoria, British Columbia, V8R 6V5, Canada
BC Cancer ? Kelowna (Sindi Ahluwalia Hawkins Centre)
RECRUITING

Kelowna, British Columbia, V1Y 5L3, Canada
Baptist Cancer Center
RECRUITING

Memphis, Tennessee, 38120, United States
Barts and the London NHS Trust
RECRUITING

London, E1 2ES, United Kingdom
Beaumont Hospital
RECRUITING

Dublin, D09V2N0, Ireland
BioResearch Partner
RECRUITING

Hialeah, Florida, 33013, United States
Blackpool Teaching Hospitals NHS Foundation Trust , Victoria Hospital
RECRUITING

Blackpool, FY3 8NR, United Kingdom
Bristol Haematology & Oncology Centre
RECRUITING

Bristol, BS2 8ED, United Kingdom
CH de Saint Quentin
RECRUITING

Saint-Quentin, 02321, France
CHU Angers
RECRUITING

Angers, 49933, France
CHU Bordeaux
RECRUITING

Pessac, 33604, France
CHU HELORA - Hôpital de Mons - Site Kennedy
RECRUITING

Mons, 7000, Belgium
CHU Montpellier
RECRUITING

Montpellier, 34295, France
CHU Strasbourg - Nouvel Hopital Civil
RECRUITING

Strasbourg, 67091, France
CHU de Liège (Sart Tilman)
RECRUITING

Liège, 4000, Belgium
CHU de Quebec - Hopital de l'Enfant-Jesus
RECRUITING

Québec, G1J 1Z4, Canada
CHVNG/E_Unidade 1
RECRUITING

Vila Nova de Gaia, 4434-502, Portugal
California Pacific Medical Center
RECRUITING

San Francisco, California, 94115, United States
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Francois Baclesse
RECRUITING

Caen, 14076, France
Centre Hospitalier Bretagne Atlantique Vannes
RECRUITING

Vannes, 56017, France
Centre Hospitalier Regional De Rimouski
RECRUITING

Rimouski, Quebec, G5L 5T1, Canada
Centre Hospitalier Universitaire de Reims
RECRUITING

Reims, 51092, France
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Centro Integrado de Oncologia de Curitiba
RECRUITING

Curitiba, Paraná, 80810-050, Brazil
Centro Oncologico Korben
RECRUITING

Ciudad Autonoma Buenos Aires, C1426AGE, Argentina
Centrum Pulmonologii i Torakochirurgii
RECRUITING

Bystra, 43-360, Poland
Charite - Universitätsmedizin Berlin
RECRUITING

Berlin, 13353, Germany
Chris Hani Baragwanath Clinical Trial Site
RECRUITING

Soweto, 2013, South Africa
Chung Shan Medical University Hospital
RECRUITING

Taichung, 40201, Taiwan
Chungbuk National University Hospital
RECRUITING

Cheongju-si, 28644, South Korea
City of Hope - Phoenix
RECRUITING

Goodyear, Arizona, 85338, United States
City of Hope® Atlanta
RECRUITING

Newnan, Georgia, 30265, United States
City of Hope® Cancer Center Chicago
RECRUITING

Zion, Illinois, 60099, United States
Clinica Adventista Belgrano
RECRUITING

Ciudad Autonoma Buenos Aires, C1430EGF, Argentina
Clinica Universidad de Navarra Madrid
RECRUITING

Madrid, 28027, Spain
Clinica Universitaria de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinical Research Alliance
RECRUITING

Westbury, New York, 11590, United States
Cliniques Universitaires St-Luc
RECRUITING

Brussels, 1200, Belgium
Community Clinical Trials
RECRUITING

Kingwood, Texas, 77339, United States
Complejo Hospitalario Universitario Insular?Materno Infantil
RECRUITING

Las Palmas de Gran Canaria, LAS Palmas, 35016, Spain
Crio - Centro Regional Integrado de Oncologia
RECRUITING

Fortaleza, Ceará, 60336-232, Brazil
Dolnoslaskie Centrum Chorob Pluc
RECRUITING

Wroclaw, 53-439, Poland
E-DA Hospital
RECRUITING

Kaohsiung City, 824, Taiwan
East Kent Hospitals University NHS Foundation Trust
RECRUITING

Canterbury, CT1 3NG, United Kingdom
Errikos Dynan Hospital
RECRUITING

Athens, 11526, Greece
Firsthealth of The Carolinas
RECRUITING

Pinehurst, North Carolina, 28374, United States
Florida Cancer Specialists - EAST - SCRI - PPDS
RECRUITING

West Palm Beach, Florida, 33401-3406, United States
Florida Cancer Specialists - NORTH - SCRI - PPDS
RECRUITING

St. Petersburg, Florida, 33701, United States
Florida Cancer Specialists - SOUTH - SCRI - PPDS
RECRUITING

Fort Myers, Florida, 33901-8108, United States
Fundação Pio XII Hospital de Câncer de Barretos
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
Groupe Hospitalier Paris Saint Joseph
RECRUITING

Paris, 75014, France
Hakodate Goryoukaku Hospital
RECRUITING

Hokkaido, 040-8611, Japan
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, 150081, China
Harbour Cancer and Wellness
RECRUITING

Auckland, 1023, New Zealand
Herlev Hospital, Afdeling for Kræftbehandling, Center for Kræftforskning, Klinisk Forskningsenhed
RECRUITING

Herlev, 2730, Denmark
Hoag Memorial Hospital
RECRUITING

Newport Beach, California, 92658, United States
Hope and Healing Cancer Services
WITHDRAWN

Hinsdale, Illinois, 60521, United States
Hopital Avicenne
RECRUITING

Bobigny, 93009, France
Hopital Tenon
RECRUITING

Paris, 75970, France
Hospital Aleman de Buenos Aires
RECRUITING

Buenos Aires, C1118AAT, Argentina
Hospital Beatriz Angelo
RECRUITING

Loures, 2674-514, Portugal
Hospital Britanico
RECRUITING

Ciudad Autonoma Buenos Aires, C1280AEB, Argentina
Hospital Civil de Guadalajara Fray Antonio Alcalde
RECRUITING

Guadalajara, Jalisco, 44280, Mexico
Hospital Clinic Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Italiano
RECRUITING

Buenos Aires, C1181ACH, Argentina
Hospital Nossa Senhora da Conceicao
RECRUITING

Porto Alegre, Rio Grande do Sul, 90040-373, Brazil
Hospital Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Son Espases
RECRUITING

Palma de Mallorca, Balearic Islands, 07014, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital de Braga
RECRUITING

Braga, 4710-243, Portugal
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
Hull University Teaching Hospitals NHS Trust
RECRUITING

Hull, HU3 2JZ, United Kingdom
Humanitas Centro Catanese Di Oncologia
RECRUITING

Misterbianco (CT), Sicily, 95045, Italy
Hunan Cancer Hospital
RECRUITING

Changsha, 410013, China
Hyogo Medical University Hospital
RECRUITING

Hyōgo, 663-8501, Japan
Hôpital Louis Pradel, Hospices Civils de Lyon
RECRUITING

Bron, 69677, France
Hôpital Universitaire de Genève (HUG)
RECRUITING

Geneva, 1211, Switzerland
IEO Istituto Europeo di Oncologia
RECRUITING

Milan, Lombardy, 20141, Italy
IPO do Porto
RECRUITING

Porto, 4200-072, Portugal
Instituto do Cancer do Estado de Sao Paulo - ICESP
RECRUITING

São Paulo, São Paulo, 01246-000, Brazil
Instytut Gruzlicy I Chorob Pluc
RECRUITING

Warsaw, 01-138, Poland
Interbalkan Medical Center of Thessaloniki
RECRUITING

Thessaloniki, 546 39, Greece
Irccs Centro Di Riferimento Oncologico (CRO)
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy
Irmandade Da Santa Casa de Misericordia de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
Isala
RECRUITING

Zwolle, 8025 AB, Netherlands
Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, Campania, 80131, Italy
JPS Health Network
RECRUITING

Fort Worth, Texas, 76104, United States
Jessa Zkh (Campus Virga Jesse)
RECRUITING

Hasselt, 3500, Belgium
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Juntendo University Hospital
RECRUITING

Tokyo, 113-8431, Japan
KEM/Evang. Kliniken Essen Mitte gGmbH
RECRUITING

Essen, 45136, Germany
KRH Klinikum Siloah-Oststadt-Heidehaus
RECRUITING

Hanover, 30459, Germany
Kagoshima University Hospital
RECRUITING

Kagoshima, 890-8520, Japan
Kanagawa Cancer Center
RECRUITING

Kanagawa, 241-8515, Japan
Kansai Medical University Hospital
RECRUITING

Osaka, 573-1191, Japan
Kantonsspital Baden
RECRUITING

Baden, 5404, Switzerland
Kantonsspital Graubünden Medizin Onkologie
RECRUITING

Chur, 7000, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Kinghorn Cancer Centre
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Klinikum Esslingen
RECRUITING

Esslingen am Neckar, 73730, Germany
Klinikum Würzburg Mitte gGmbH
RECRUITING

Würzburg, 97074, Germany
Korea University Guro Hospital
RECRUITING

Seoul, 8308, South Korea
Krakowski Szpital Specjalistyczny im sw.Jana Pawla II
RECRUITING

Krakow, 31-202, Poland
Krankenhaus Martha-Maria Halle-Doelau gGmbH
RECRUITING

Halle, 06120, Germany
Kurume University Hospital
RECRUITING

Fukuoka, 830-0011, Japan
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, 41404, South Korea
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
Liga Norte Riograndense Contra O Câncer
RECRUITING

Natal, Rio Grande do Norte, 59040150, Brazil
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia
Lungenfachklinik Immenhausen
RECRUITING

Immenhausen, 34376, Germany
Maidstone and Tunbridge Wells NHS Trust
RECRUITING

Maidstone, ME16 9QQ, United Kingdom
Marin Cancer Care Inc
RECRUITING

Greenbrae, California, 94904, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mater Misecordiae University Hospital
RECRUITING

Dublin, Dublin 7, Ireland
Matrai Gyogyintezet
RECRUITING

Mátraháza, 3233, Hungary
Mazowiecki Szpital Onkologiczny
RECRUITING

Wieliszew, 05-135, Poland
Meander Medisch Centrum
RECRUITING

Amersfoort, Utrecht, 3813 TZ, Netherlands
Memorial Healthcare System - Memorial Regional Hospital
RECRUITING

Hollywood, Florida, 33021, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Montefiore Einstein Cancer Center
RECRUITING

The Bronx, New York, 10461, United States
NHO Revive Research Institute
RECRUITING

Lincoln, Nebraska, 68506, United States
National Cancer Centre
RECRUITING

Singapore, 168583, Singapore
National Taiwan University Cancer Center
RECRUITING

Zhongzheng Dist., 106, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 00100, Taiwan
National University Hospital
RECRUITING

Singapore, 119228, Singapore
Niigata University Medical & Dental Hospital
RECRUITING

Niigata, 951-8520, Japan
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Onkologisk Ambulatorium - Sønderborg
RECRUITING

Sønderborg, 6400, Denmark
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Osaka Metropolitan University Hospital
RECRUITING

Osaka, 545-8586, Japan
Ospedale Giuseppe Moscati
RECRUITING

Statte, Apulia, 74010, Italy
Ospedale P. Pederzoli Casa di cura Privata
RECRUITING

Peschiera Del Garda (VR), Veneto, 37019, Italy
Oxford University Hospitals NHS Trust - Churchill Hospital
RECRUITING

Oxford, OX3 7LE, United Kingdom
Palo Alto Medical Foundation Research Center
RECRUITING

Palo Alto, California, 94301, United States
Peter Maccallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Piedmont Cancer Institute, PC
RECRUITING

Atlanta, Georgia, 30318, United States
Pius Hospital Oldenburg
RECRUITING

Oldenburg, 26121, Germany
Policlinico Universitario "Agostino Gemelli"
RECRUITING

Rome, Lazio, 00168, Italy
Presidio san salvatore muraglia
RECRUITING

Pesaro, Emilia-Romagna, 61122, Italy
Prince of Wales Hosp
RECRUITING

Shatin, Hong Kong
Profound Research, LLC
RECRUITING

Farmington Hills, Michigan, 48334, United States
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
Pécsi Tudományegyetem
RECRUITING

Pécs, 7623, Hungary
Queen Elizabeth Hospital Department of Clinical Oncology
RECRUITING

Kowloon, 000000, Hong Kong
Queen Mary Hospital
RECRUITING

Hong Kong, Hong Kong
Radomskie Centrum Onkologii
RECRUITING

Radom, 26-600, Poland
Reading Hospital - McGlinn Cancer Institute
RECRUITING

West Reading, Pennsylvania, 19611, United States
Református Pulmonológiai Centrum
RECRUITING

Törökbálint, 2045, Hungary
Renovatio Clinical
RECRUITING

The Woodlands, Texas, 77380, United States
Renovatio Clinical - El Paso
RECRUITING

El Paso, Texas, 79915, United States
Rigshospitalet
RECRUITING

København Ø, 2100, Denmark
Royal Hobart Hospital
RECRUITING

Hobart, Tasmania, 7000, Australia
Royal Marsden Hospital - Fulham
RECRUITING

London, SW3 6JJ, United Kingdom
Royal Marsden NHS Foundation Trust
RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Victoria Regional Health Centre
RECRUITING

Barrie, Ontario, L4M 6M2, Canada
SLK Kliniken Heilbronn GmbH, Standort Fachklinik Löwenstein
RECRUITING

Löwenstein, 74245, Germany
Saint Agnes Hospital - Baltimore - Hunt - PPDS
RECRUITING

Baltimore, Maryland, 21229-5201, United States
San Juan Oncology Associates
RECRUITING

Farmington, New Mexico, 87401, United States
Sarah Cannon Research Institute
RECRUITING

London, W1G 6AD, United Kingdom
Saskatoon Cancer Centre
RECRUITING

Saskatoon, Saskatchewan, S7N 4H4, Canada
Sendai Kousei Hospital
RECRUITING

Miyagi, 981-0914, Japan
Seoul National University Hospital
RECRUITING

Seoul, 110-744, South Korea
Shanghai East Hospital
RECRUITING

Shanghai, 200120, China
Shanghai Pulmonary Hospital
RECRUITING

Shanghai, 200433, China
Sir Run Run Shaw Hospital Zhejiang University
RECRUITING

Hangzhou, 310016, China
Sjællands Universitetshospital, Roskilde
RECRUITING

Roskilde, 4000, Denmark
Sotiria General Hospital of Athens
RECRUITING

Athens, 115 27, Greece
St James Hospital
RECRUITING

Dublin, D08 NHY1, Ireland
St. Luke's Cancer Institute
RECRUITING

Boise, Idaho, 83712, United States
St. Luke's University Health Network
RECRUITING

Bethlehem, Pennsylvania, 18015, United States
Summit Cancer Care PC
RECRUITING

Savannah, Georgia, 31405, United States
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
Sutter Institute for Medical Research
RECRUITING

Roseville, California, 95661, United States
Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Tallaght Hospital
RECRUITING

Dublin, D24 NR0A, Ireland
Technische Universität Dresden - Medizinische Fakultät Carl Gustav Carus;Medizinische Klinik und Poliklinik I
RECRUITING

Dresden, 01307, Germany
Texas Tech Health Science Center
RECRUITING

Lubbock, Texas, 79415, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Tokyo, 135-8550, Japan
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-4000, United States
Theageneion Anticancer Hospital
RECRUITING

Thessaloniki, 54639, Greece
Tohoku University Hospital
RECRUITING

Sendai, 980-8574, Japan
Tokyo Medical University Hospital
RECRUITING

Tokyo, 160-0023, Japan
Tuen Mun Hospital
RECRUITING

Hong Kong, Hong Kong
USL 6 Toscana Nord Ovest ? P.O. Livorno
RECRUITING

Livorno, Tuscany, 57124, Italy
UZ Brussel
RECRUITING

Brussels, 1090, Belgium
UZ Leuven Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Universitaetsspital Basel
RECRUITING

Basel, 4031, Switzerland
University Hospital of Larissa
RECRUITING

Larissa, 411 10, Greece
University of Florida Health at Shands
RECRUITING

Gainesville, Florida, 32610, United States
University of Texas Health Center at Tyler
RECRUITING

Tyler, Texas, 75708, United States
Universität Des Saarlandes
RECRUITING

Homburg, 66421, Germany
Universität Mannheim
RECRUITING

Mannheim, 68167, Germany
Universitätsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitätsklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany
Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
RECRUITING

Lublin, 20-954, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gda?sk, 80-214, Poland
Velindre NHS Trust - Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Vincentius-Diakonissen-Kliniken gAG
RECRUITING

Karlsruhe, 76137, Germany
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Vivantes - Klinikum Im Friedrichshain;Innere Medizin ? Hämatologie, Onkologie und Palliativmedizin
RECRUITING

Berlin, 10249, Germany
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641-8510, Japan
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
RECRUITING

Olsztyn, 10-357, Poland
Wellington Hospital
RECRUITING

Newtown, 6021, New Zealand
West China Hospital - Sichuan University
RECRUITING

Chengdu, 611130, China
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu
RECRUITING

Poznan, 60-569, Poland
William Osler Health Centre - Brampton Civic Hospital
RECRUITING

Brampton, Ontario, L6R 3J7, Canada
Wits Donald Gordon Clinical Trial Centre
RECRUITING

Parktown, South Africa
Ziekenhuis Rijnstate
RECRUITING

Arnhem, 6815 AD, Netherlands
Ziekenhuis St. Jansdal
RECRUITING

Harderwijk, 3844 DG, Netherlands

Conditions

Explore the condition pages connected to this study.

KRAS G12C LUNG CANCER KRAS G12C LUNG CANCER NON-SMALL CELL LUNG CANCER