Heart drug digoxin tested to slow ALS progression

NCT ID NCT07047209

First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 28 times

Summary

This phase 2a trial tests whether the heart medication digoxin is safe and can slow nerve damage in people with ALS. About 40 adults with early-stage ALS will take oral digoxin for 24 weeks. Researchers will monitor side effects and measure blood markers of nerve health to see if the drug has a protective effect.

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Contacts and locations

Locations

  • MGH

    Boston, Massachusetts, 02114, United States

  • Northwestern Universsity

    Chicago, Illinois, 60611, United States

  • Nova Southeastern University

    Davie, Florida, 33314, United States

Conditions

Explore the condition pages connected to this study.