A blood and stool test could spot digestive cancers before they spread

NCT ID NCT07769892

NEW Recruiting now Diagnosis Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This study is testing whether a combination of blood and stool biomarkers can accurately screen for cancers of the digestive tract, including stomach, esophagus, and colon. Researchers will collect blood and stool samples from 5,000 people aged 45-74 who are already scheduled for an endoscopy. The test results will be compared against endoscopy and biopsy findings to see how sensitive and specific the new screening method is, with participants followed for five years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combined blood multi-gene methylation test and fecal biomarkers (FIT and calprotectin)
What this could lead to: If successful, this could lead to a simple, non-invasive screening method for early detection of digestive tract cancers, potentially reducing cancer deaths.
What could go wrong: The test may not be accurate enough to replace endoscopy, and early results may not hold up in larger, more diverse populations. False positives or negatives remain a risk.

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Conditions

The condition(s) this trial relates to.

digestive system cancer digestive system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL CANCERS

Contacts and locations

Locations

Gaoyao District People's Hospital, Zhaoqing City, Guangdong Province
RECRUITING

Zhaoqing, Guangdong, China
The 960th Hospital of the Joint Support Force of the People's Liberation Army of China
RECRUITING

Jinan, China
The First Affiliated Hospital of Air Force Military Medical University
RECRUITING

Xi'an, Shaanxi, 710032, China
Wuwei Cancer Hospital of Gansu Province
RECRUITING

Wuwei, China
Wuxi People's Hospital
RECRUITING

Wuxi, China
Yanting County Tumor Hospital
RECRUITING

Mianyang, China
Zhaoqing First People's Hospital, Guangdong Province
RECRUITING

Zhaoqing, China

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