Can diet and exercise slow prostate Cancer's return after surgery?
NCT ID NCT03999151
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This study tests whether different combinations of diet and exercise support tools—like educational materials, text messaging, and coaching—can improve outcomes for men with prostate cancer who choose surgery. Researchers will track PSA recurrence and quality of life over time. The goal is to see if lifestyle changes can help delay or prevent cancer from coming back.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a behavioral program combining educational materials, text messaging, and coaching on diet and exercise
- What this could lead to
- If successful, this could show that lifestyle changes help delay prostate cancer recurrence after surgery, offering a non-drug way to improve outcomes.
- What could go wrong
- This is a relatively small trial testing behavioral tools, not a drug, so the effects may be modest. Results may not apply to all men with prostate cancer.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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204 people
The number who actually took part.
- Started
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May 2018
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age \>=18 years 2. Diagnosed with non-metastatic prostate cancer and choose radical prostatectomy (RP) as primary treatment. 3. Able to speak and read English 4. Regular access to the Internet (via a computer, tablet, or phone) and text messaging capabilities on the phone 5. Ability to understand a written informed consent document, and the willingness to sign it Exclusion Criteria: 1. Cannot have neoadjuvant radiation or hormone therapy planned at time of enrollment (if enrolling \>4 weeks prior to RP). 2. Men who have contraindications to exercise based the American College of Sports Medicine 2016 Exercise pre-participation screening criteria (https://www.ncbi.nlm.nih.gov/pubmed/26473759), and who do not receive a physician clearance to participate in the moderate to vigorous intensity physical activity with one or more of the following self-reported conditions: 1. Heart attack 2. Heart surgery, cardiac catheterization, or coronary angioplasty 3. Pacemaker/implantable cardiac defibrillator/rhythm disturbance 4. Heart valve disease 5. Heart failure 6. Heart transplantation 7. Congenital heart disease 8. Diabetes 9. Kidney (renal) disease 10. Chest discomfort with exertion 11. Unreasonable breathlessness 12. Dizziness, fainting, or blackouts 13. Ankle swelling 14. Unpleasant awareness of forceful, rapid or irregular heart rate 15. Burning or cramping sensations in your lower legs when walking short distance 3. Men already meeting aerobic AND resistance exercise recommendations. To be eligible, must not meet at least one of the following: (1) 150 minutes per week of planned moderate aerobic exercise or 75 minutes per week of planned vigorous aerobic exercise or combination;(2) Two or more days per week of resistance exercise; (3) Eight or more resistance exercises per session 4. Men who are already meeting all of the 7 prostate-specific dietary recommendations
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California, San Francisco (UCSF)
San Francisco, California, 94143, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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