New eye drug shows promise for Diabetes-Related vision loss
NCT ID NCT06847854
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study tests a new drug, RO7497372, given as an eye injection for people with diabetic macular edema (DME), a condition that causes vision loss. The trial involves 151 participants and aims to check the drug's safety, how long it stays in the eye and blood, and its effects. It is split into two parts: first, testing different doses openly, then comparing two doses in a masked study.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RO7497372 (injected into the eye)
What this could lead to
If successful, this could lead to a new treatment option for diabetic macular edema, potentially reducing vision loss.
What could go wrong
This is an early Phase 1 trial with only 151 participants, so safety and effectiveness are not yet proven. There are risks of eye inflammation or other side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arkansas Retina Research
Little Rock, Arkansas, 72205, United States
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Associated Retina Consultants
Phoenix, Arizona, 85020, United States
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Austin Clinical Research LLC
Austin, Texas, 78750, United States
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Barnet Dulaney Perkins Eye Center
Mesa, Arizona, 85206, United States
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Bay Area Retina Associates
Walnut Creek, California, 94598, United States
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Brown Retina Institute
Schertz, Texas, 78154, United States
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Carolina Eyecare Physicians
Mt. Pleasant, South Carolina, 29464, United States
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Center for Retina and Macula Disease
Winter Haven, Florida, 33880, United States
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Charles Retina Institute
Germantown, Tennessee, 38138, United States
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Cleveland Clinic
Cleveland, Ohio, 44106, United States
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Cumberland Valley Retina PC
Hagerstown, Maryland, 21740, United States
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East Florida Eye Institute
Stuart, Florida, 34994, United States
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Emanuelli Research and Development Center
Arecibo, 00612, Puerto Rico
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Emerson Clinical Research Institute
Falls Church, Virginia, 78503, United States
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Erie Retinal Surgery
Erie, Pennsylvania, 16507, United States
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EyeHealth Northwest
Portland, Oregon, 97225, United States
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Florida Eye Associates
Melbourne, Florida, 32901, United States
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Foundation for Vision Research
Grand Rapids, Michigan, 49546, United States
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Global Research Management
Glendale, California, 91204, United States
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Medeye Associates
South Miami, Florida, 33143, United States
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Mid Atlantic Retina
Philadelphia, Pennsylvania, 19107, United States
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Mississippi Retina Associates
Madison, Mississippi, 39202, United States
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Piedmont Eye Center
Lynchburg, Virginia, 24502, United States
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Retina Associates of Michigan
Grand Blanc, Michigan, 48439-8301, United States
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Retina Associates of NY
New York, New York, 10075, United States
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Retina Consultants Minnesota
Saint Louis Park, Minnesota, 55416, United States
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Retina Consultants of Texas
The Woodlands, Texas, 77384, United States
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Retina Group of Washington
Fairfax, Virginia, 20815, United States
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Retina Specialists of Tampa
Wesley Chapel, Florida, 33544, United States
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Retinal Consultants Medical Group
Modesto, California, 95356, United States
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Retinal Consultants of AZ, Ltd
Peoria, Arizona, 85381, United States
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Ross Eye Institute
Buffalo, New York, 14209-2102, United States
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Salt Lake Retina
West Jordan, Utah, 84088, United States
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Sierra Eye Associates
Reno, Nevada, 89502, United States
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Spokane Eye Clinical Research
Spokane, Washington, 99204-2509, United States
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The Retina Institute
St Louis, Missouri, 63128, United States
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Verum Research LLC
Eugene, Oregon, 97401, United States
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Wagner Kapoor Institute
Norfolk, Virginia, 23502, United States