New eye drug shows promise for Diabetes-Related vision loss

NCT ID NCT06847854

Ongoing Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests a new drug, RO7497372, given as an eye injection for people with diabetic macular edema (DME), a condition that causes vision loss. The trial involves 151 participants and aims to check the drug's safety, how long it stays in the eye and blood, and its effects. It is split into two parts: first, testing different doses openly, then comparing two doses in a masked study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RO7497372 (injected into the eye)
What this could lead to: If successful, this could lead to a new treatment option for diabetic macular edema, potentially reducing vision loss.
What could go wrong: This is an early Phase 1 trial with only 151 participants, so safety and effectiveness are not yet proven. There are risks of eye inflammation or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

Locations

Arkansas Retina Research

Little Rock, Arkansas, 72205, United States
Associated Retina Consultants

Phoenix, Arizona, 85020, United States
Austin Clinical Research LLC

Austin, Texas, 78750, United States
Barnet Dulaney Perkins Eye Center

Mesa, Arizona, 85206, United States
Bay Area Retina Associates

Walnut Creek, California, 94598, United States
Brown Retina Institute

Schertz, Texas, 78154, United States
Carolina Eyecare Physicians

Mt. Pleasant, South Carolina, 29464, United States
Center for Retina and Macula Disease

Winter Haven, Florida, 33880, United States
Charles Retina Institute

Germantown, Tennessee, 38138, United States
Cleveland Clinic

Cleveland, Ohio, 44106, United States
Cumberland Valley Retina PC

Hagerstown, Maryland, 21740, United States
East Florida Eye Institute

Stuart, Florida, 34994, United States
Emanuelli Research and Development Center

Arecibo, 00612, Puerto Rico
Emerson Clinical Research Institute

Falls Church, Virginia, 78503, United States
Erie Retinal Surgery

Erie, Pennsylvania, 16507, United States
EyeHealth Northwest

Portland, Oregon, 97225, United States
Florida Eye Associates

Melbourne, Florida, 32901, United States
Foundation for Vision Research

Grand Rapids, Michigan, 49546, United States
Global Research Management

Glendale, California, 91204, United States
Medeye Associates

South Miami, Florida, 33143, United States
Mid Atlantic Retina

Philadelphia, Pennsylvania, 19107, United States
Mississippi Retina Associates

Madison, Mississippi, 39202, United States
Piedmont Eye Center

Lynchburg, Virginia, 24502, United States
Retina Associates of Michigan

Grand Blanc, Michigan, 48439-8301, United States
Retina Associates of NY

New York, New York, 10075, United States
Retina Consultants Minnesota

Saint Louis Park, Minnesota, 55416, United States
Retina Consultants of Texas

The Woodlands, Texas, 77384, United States
Retina Group of Washington

Fairfax, Virginia, 20815, United States
Retina Specialists of Tampa

Wesley Chapel, Florida, 33544, United States
Retinal Consultants Medical Group

Modesto, California, 95356, United States
Retinal Consultants of AZ, Ltd

Peoria, Arizona, 85381, United States
Ross Eye Institute

Buffalo, New York, 14209-2102, United States
Salt Lake Retina

West Jordan, Utah, 84088, United States
Sierra Eye Associates

Reno, Nevada, 89502, United States
Spokane Eye Clinical Research

Spokane, Washington, 99204-2509, United States
The Retina Institute

St Louis, Missouri, 63128, United States
Verum Research LLC

Eugene, Oregon, 97401, United States
Wagner Kapoor Institute

Norfolk, Virginia, 23502, United States

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