First patients test experimental cancer drug in early safety trial

NCT ID NCT06108479

Summary

This first-in-human study tested the safety of a new cancer drug called DF6215, both alone and combined with an existing immunotherapy (pembrolizumab), in adults with advanced solid tumors that couldn't be removed by surgery, had returned, or had spread. The main goals were to find safe dose levels and check for side effects in 35 participants. This was an early Phase 1 trial, so it focused on safety rather than proving how well the treatment works.

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Contacts and locations

Locations

  • CHU de Marseille - Hôpital de la Timone

    Marseille, 13005, France

  • Cancer Research SA (CRSA)

    Adelaide, South Australia, 5000, Australia

  • Centre Georges François Leclerc

    Dijon, 21000, France

  • Centre Hospitalier Universitaire de Bordeaux

    Bordeaux, 33075, France

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers, 86000, France

  • Hôpital Lyon-Sud

    Pierre-Bénite, 69495, France

  • Institut Bergonié

    Bordeaux, 33000, France

  • Institut Curie

    Paris, 75005, France

  • Institut Paoli-Calmettes

    Marseille, 13009, France

  • Institut Universitaire du Cancer de Toulouse Oncopole

    Toulouse, 31100, France

  • Institut de Cancérologie de l'Ouest - Saint-Herblain - Site René Gauducheau

    Saint-Herblain, 44805, France

  • Lifespan - Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • NYU Langone Health

    New York, New York, 10016, United States

  • Peninsula and South East Oncology Medical (PASO)

    Frankston, Victoria, 3199, Australia

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203, United States

  • Sarcoma Oncology Center

    Santa Monica, California, 90403, United States

  • Tampa General Hospital

    Tampa, Florida, 33606, United States

  • The Angeles Clinic and Research Institute - West Los Angeles Office

    Los Angeles, California, 90025, United States

  • University of California Irvine Medical Center

    Orange, California, 92868, United States

  • University of California San Diego Moores Cancer Center

    San Diego, California, 92093, United States

Conditions

Explore the condition pages connected to this study.