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Can a sedative keep older Patients' minds clear after knee surgery?

NCT ID NCT05707741

Prevention Sponsor: Menoufia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This pilot trial investigates whether the sedative drug dexmedetomidine can prevent postoperative delirium—a state of confusion and altered awareness—in older adults undergoing total knee replacement under spinal anesthesia. Researchers will compare two different doses of the drug against a placebo in 45 patients aged 65 to 75. The goal is to see if this approach can safely reduce the risk of delirium after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If effective, this could point toward a simple way to reduce confusion and delirium after surgery in older adults.
What could go wrong
This is a small pilot study, so results may not be definitive. The drug may not prevent delirium and could have side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Jun 2023

Finished

Feb 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA physical status I- II * Age from 65to 75 years old, * Elective total knee arthroplasty under spinal anaesthesia. Exclusion Criteria: * Bleeding disorders * Allergy to any of the drugs used in the study * Renal insufficiency * Liver failure-Neurological abnormalities -patients with hearing and visual impairment

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Conditions

The condition(s) this trial relates to.

delirium Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative delirium

Contacts and locations

Locations

  • Menoufia University

    Menoufia, Menoufia, 32817, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.